| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5265273 | B | Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire High Throughput Mass spectrometry | Homo sapiens | 63 | cell-based format | Scientific Literature | ||
| 2. | ALA5265274 | B | Inhibition of H-PGDS in rat RBL cells assessed as reduction in A23187-induced PGD2 production pretreated for 30 mins followed by A23187 addition for 30 mins by RapidFire Mass spectrometry | Rattus norvegicus | 63 | cell-based format | Scientific Literature | ||
| 3. | ALA5265276 | A | Half life in mouse liver microsomes pretreated for 5 mins followed by incubation with NADP for 30 secs and measured upto 45 mins by LC-MS/MS analysis | Mus musculus | 21 | microsome format | Scientific Literature | ||
| 4. | ALA5265277 | A | Dose normalized AUC in mouse at 3 mg/kg, po | Mus musculus | 29 | organism-based format | Scientific Literature | ||
| 5. | ALA5265278 | A | Solubility of the compound in FaSSIF at pH 6.5 measured after 4 hrs by HPLC-UV analysis | 28 | assay format | Scientific Literature | |||
| 6. | ALA5265279 | A | Apparent permeability, Papp of the compound at pH 7.4 incubated for 3 hrs by AMP based liquid chromatography | 26 | assay format | Scientific Literature | |||
| 7. | ALA5265280 | A | Protein binding in human serum albumin by HPLC analysis | Homo sapiens | 27 | cell-free format | Scientific Literature | ||
| 8. | ALA5265281 | A | Terminal half life in mouse at 1 mg/kg, iv | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA5265282 | A | Clearance in mouse at 1 mg/kg, iv | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 10. | ALA5265283 | A | Volume of distribution at steady state in mouse at 1 mg/kg, iv | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 11. | ALA5265284 | A | Oral bioavailability in mouse at 3 mg/kg | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 12. | ALA5265285 | A | Ratio of drug level in brain to blood in mouse at 1 mg/kg, iv | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 13. | ALA5265286 | A | Terminal half life in rat at 0.4 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA5265287 | A | Clearance in rat at 0.4 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA5265288 | A | Volume of distribution at steady state in rat at 0.4 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5265289 | A | Oral bioavailability in rat at 2.4 mg/kg | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5265290 | A | Terminal half life in dog at 0.5 mg/kg, iv | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5265291 | A | Clearance in dog at 0.5 mg/kg, iv | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5265292 | A | Volume of distribution at steady state in dog at 0.5 mg/kg, iv | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5265293 | A | Oral bioavailability in dog at 1 mg/kg | Canis lupus familiaris | 1 | organism-based format | Scientific Literature |
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