# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5256771 | Binding | Agonist activity at human mGluR7 expressed in CHO cells expressing CRE-Luc reporter gene assessed as reduction in forskolin-stimulated cAMP production preincubated for 15 mins followed by forskolin stimulation and measured after 5 hrs by luminescence based Steady glo assay | Homo sapiens | 8 | ALA5252666 | cell-based format | Scientific Literature | |
2. | ALA5256772 | Binding | Agonist activity at human mGluR7 expressed in CHO cells expressing CRE-Luc reporter gene assessed as reduction in forskolin-stimulated cAMP production by measuring maximum efficacy preincubated for 15 mins followed by forskolin stimulation and measured after 5 hrs by luminescence based Steady glo assay relative to control | Homo sapiens | 8 | ALA5252666 | cell-based format | Scientific Literature | |
3. | ALA5256773 | ADME | Stability in human liver microsomes assessed as intrinsic clearance preincubated for 60 mins followed by NADPH addition and measured upto 60 mins by LC-MS/MS analysis | Homo sapiens | 7 | ALA5252666 | microsome format | Scientific Literature | |
4. | ALA5256774 | ADME | Stability in rat liver microsomes assessed as intrinsic clearance preincubated for 60 mins followed by NADPH addition and measured upto 60 mins by LC-MS/MS analysis | Rattus norvegicus | 7 | ALA5252666 | microsome format | Scientific Literature | |
5. | ALA5256775 | ADME | Stability in cryopreserved human hepatocytes assessed as clearance measured for 120 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA5252666 | cell-based format | Scientific Literature | |
6. | ALA5256776 | ADME | Stability in cryopreserved rat hepatocytes assessed as clearance measured for 120 mins by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA5252666 | cell-based format | Scientific Literature | |
7. | ALA5256777 | ADME | Unbound fraction in rat plasma incubated for 6 hrs by LC-MS/MS based rapid equilibrium dialysis | Rattus norvegicus | 2 | ALA5252666 | cell-free format | Scientific Literature | |
8. | ALA5256778 | ADME | Unbound fraction in rat brain incubated for 6 hrs by LC-MS/MS based rapid equilibrium dialysis | Rattus norvegicus | 2 | ALA5252666 | tissue-based format | Scientific Literature | |
9. | ALA5256779 | ADME | Apparent permeability from apical to basolateral side in MDCK-MDR1 cells | Canis lupus familiaris | 2 | ALA5252666 | cell-based format | Scientific Literature | |
10. | ALA5256780 | ADME | Efflux ratio of apparent permeability in MDCK-MDR1 cells | Canis lupus familiaris | 2 | ALA5252666 | cell-based format | Scientific Literature | |
11. | ALA5256781 | ADME | Clearance in Sprague-Dawley rat plasma at 0.5 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA5252666 | organism-based format | Scientific Literature | |
12. | ALA5256782 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 0.5 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA5252666 | organism-based format | Scientific Literature | |
13. | ALA5256783 | ADME | Oral bioavailability in Sprague-Dawley rat at 3 mg/kg measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA5252666 | organism-based format | Scientific Literature | |
14. | ALA5256784 | ADME | Cmax in Sprague-Dawley rat at 3 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA5252666 | organism-based format | Scientific Literature | |
15. | ALA5256785 | ADME | Tmax in Sprague-Dawley rat at 3 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA5252666 | organism-based format | Scientific Literature | |
16. | ALA5256786 | ADME | Half-life in Sprague-Dawley rat at 3 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA5252666 | organism-based format | Scientific Literature | |
17. | ALA5256787 | ADME | AUC(0 to infinity) in Sprague-Dawley rat at 3 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA5252666 | organism-based format | Scientific Literature | |
18. | ALA5256788 | ADME | Ratio of drug concentration in Sprague-Dawley rat brain to plasma at 3 mg/kg, po measured after 4 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA5252666 | organism-based format | Scientific Literature | |
19. | ALA5256789 | ADME | Ratio of unbound brain to plasma concentration in Sprague-Dawley rat at 3 mg/kg, po measured after 4 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA5252666 | organism-based format | Scientific Literature |