# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5240518 | Functional | Antiproliferative activity against human MM1.S cells assessed as inhibition of cell growth incubated for 72 hrs MTS assay | Homo sapiens | 12 | ALA5236646 | cell-based format | Scientific Literature | |
2. | ALA5240519 | Functional | Antiproliferative activity against human MM4-11 cells assessed as inhibition of cell growth incubated for 72 hrs MTS assay | Homo sapiens | 12 | ALA5236646 | cell-based format | Scientific Literature | |
3. | ALA5240520 | Binding | Protac activity at CRBN/BRD4 in human MM1.S cells assessed as downregulation of MYC protein expression at 300 uM incubated for 3 hrs by Western blot analysis | Homo sapiens | 4 | ALA5236646 | cell-based format | Scientific Literature | |
4. | ALA5240525 | Binding | Protac activity at CRBN/BRD4 in human MM1.S cells assessed as induction of BRD4 protein degradation by measuring residual activity at 0.03 uM incubated for 3 hrs by Western blot analysis relative to control | Homo sapiens | 4 | ALA5236646 | cell-based format | Scientific Literature | |
5. | ALA5240530 | Binding | Protac activity at CRBN/BRD4 in human MM1.S cells assessed as induction of BRD4 protein degradation by measuring residual activity at 0.1 uM incubated for 3 hrs by Western blot analysis relative to control | Homo sapiens | 4 | ALA5236646 | cell-based format | Scientific Literature | |
6. | ALA5240531 | Binding | Protac activity at CRBN/BRD4 in human MM1.S cells assessed as induction of BRD4 protein degradation by measuring residual activity at 0.3 uM incubated for 3 hrs by Western blot analysis relative to control | Homo sapiens | 4 | ALA5236646 | cell-based format | Scientific Literature | |
7. | ALA5240545 | Binding | Protac activity at CRBN/BRD4 in human MV4-11 cells assessed as induction of BRD4 protein degradation by measuring residual activity at 0.003 uM incubated for 3 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA5236646 | cell-based format | Scientific Literature | |
8. | ALA5240546 | Binding | Protac activity at CRBN/BRD4 in human MV4-11 cells assessed as induction of BRD4 protein degradation by measuring residual activity at 0.009 uM incubated for 3 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA5236646 | cell-based format | Scientific Literature | |
9. | ALA5240547 | Binding | Protac activity at CRBN/BRD4 in human MV4-11 cells assessed as induction of BRD4 protein degradation by measuring residual activity at 0.027 uM incubated for 3 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5236646 | cell-based format | Scientific Literature |