# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5258858 | Binding | Positive allosteric modulation of human GPR40 by calcium based FLIPR analysis | Homo sapiens | 36 | ALA5257080 | single protein format | Scientific Literature | |
2. | ALA5258859 | Binding | Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulation | Homo sapiens | 4 | ALA5257080 | cell-based format | Scientific Literature | |
3. | ALA5258860 | Binding | Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulation by measuring maximum efficacy | Homo sapiens | 4 | ALA5257080 | cell-based format | Scientific Literature | |
4. | ALA5258861 | Physicochemical | Lipophilicity, logD of compound | 6 | ALA5257080 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA5258862 | Binding | Positive allosteric modulation of mouse GPR40 | Mus musculus | 3 | ALA5257080 | single protein format | Scientific Literature | |
6. | ALA5258863 | ADME | Metabolic stability in mouse liver microsome assessed as parent compound remaining after 10 mins | Mus musculus | 2 | ALA5257080 | microsome format | Scientific Literature | |
7. | ALA5258866 | ADME | Cmax in mouse at 1 mg/kg | Mus musculus | 3 | ALA5257080 | organism-based format | Scientific Literature | |
8. | ALA5258867 | ADME | AUC (0-7hrs) in mouse at 1 mg/kg | Mus musculus | 3 | ALA5257080 | organism-based format | Scientific Literature | |
9. | ALA5258868 | ADME | Metabolic stability in human liver microsome assessed as parent compound remaining after 10 mins | Homo sapiens | 1 | ALA5257080 | microsome format | Scientific Literature | |
10. | ALA5258869 | ADME | Metabolic stability in rat liver microsome assessed as parent compound remaining after 10 mins | Rattus norvegicus | 1 | ALA5257080 | microsome format | Scientific Literature | |
11. | ALA5258870 | ADME | Plasma protein binding in mouse assessed as fraction unbound | Mus musculus | 1 | ALA5257080 | cell-free format | Scientific Literature | |
12. | ALA5258871 | ADME | Plasma protein binding in human assessed as fraction unbound | Homo sapiens | 1 | ALA5257080 | cell-free format | Scientific Literature | |
13. | ALA5258872 | ADME | Cmax in rat at 1 mg/kg, po | Rattus norvegicus | 1 | ALA5257080 | organism-based format | Scientific Literature | |
14. | ALA5258873 | ADME | Cmax in mouse at 1 mg/kg, po | Mus musculus | 1 | ALA5257080 | organism-based format | Scientific Literature | |
15. | ALA5258874 | ADME | Total AUC in mouse at 1 mg/kg, po | Mus musculus | 1 | ALA5257080 | organism-based format | Scientific Literature | |
16. | ALA5258875 | ADME | Total AUC in rat at 1 mg/kg, po | Rattus norvegicus | 1 | ALA5257080 | organism-based format | Scientific Literature | |
17. | ALA5258876 | ADME | Half life in mouse at 3 mg/kg, iv | Mus musculus | 1 | ALA5257080 | organism-based format | Scientific Literature | |
18. | ALA5258877 | ADME | Half life in rat at 3 mg/kg, iv | Rattus norvegicus | 1 | ALA5257080 | organism-based format | Scientific Literature | |
19. | ALA5258878 | ADME | Volume of distribution at steady state in mouse at 3 mg/kg, iv | Mus musculus | 1 | ALA5257080 | organism-based format | Scientific Literature | |
20. | ALA5258879 | ADME | Volume of distribution at steady state in rat at 3 mg/kg, iv | Rattus norvegicus | 1 | ALA5257080 | organism-based format | Scientific Literature |