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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA5223843 Binding Partial agonist activity at human 5HT4E receptor expressed in CHO cells assessed as cAMP accumulation incubated for 4 hrs by luciferase reporter gene luminescence assay Homo sapiens 73 ALA5223084 cell-based format Scientific Literature 2. ALA5223844 Binding Partial agonist activity at human 5HT4E receptor expressed in CHO cells assessed as cAMP accumulation incubated for 4 hrs by luciferase reporter gene luminescence assay relative to control Homo sapiens 68 ALA5223084 cell-based format Scientific Literature 3. ALA5223845 ADME Drug metabolism in rat liver microsomes incubated for 30 mins in presence of NADPH by LC-MS/MS analysis Rattus norvegicus 26 ALA5223084 microsome format Scientific Literature 4. ALA5223846 ADME Drug metabolism in human liver microsomes incubated for 30 mins in presence of NADPH by LC-MS/MS analysis Homo sapiens 26 ALA5223084 microsome format Scientific Literature 5. ALA5223847 Toxicity Inhibition of hERG expressed in HEK293 cells at holding potential of -80 mV by whole cell patch clamp assay Homo sapiens 11 ALA5223084 cell-based format Scientific Literature 6. ALA5223848 Toxicity Inhibition of hERG expressed in HEK293 cells at holding potential of -80 mV by whole cell patch clamp assay relative to control Homo sapiens 11 ALA5223084 cell-based format Scientific Literature 7. ALA5223852 ADME Oral bioavailability in Wistar rat at 3 mg/kg measured for 24 hrs by LC-MS/MS analysis Rattus norvegicus 19 ALA5223084 organism-based format Scientific Literature 8. ALA5223853 ADME Cmax in Wistar rat at 3 mg/kg, po and 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis Rattus norvegicus 19 ALA5223084 organism-based format Scientific Literature 9. ALA5223854 ADME AUC in Wistar rat at 3 mg/kg, po and 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis Rattus norvegicus 19 ALA5223084 organism-based format Scientific Literature 10. ALA5223855 ADME Elimination half life in Wistar rat at 3 mg/kg, po and 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis Rattus norvegicus 19 ALA5223084 organism-based format Scientific Literature 11. ALA5223856 ADME Volume of distribution at steady state in Wistar rat at 3 mg/kg, po and 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis Rattus norvegicus 19 ALA5223084 organism-based format Scientific Literature 12. ALA5223857 ADME Clearance in Wistar rat at 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis Rattus norvegicus 19 ALA5223084 organism-based format Scientific Literature 13. ALA5223858 ADME Ratio of drug level in Wistar rat brain to plasma at 10 mg/kg, po measured after 1 hr by LC-MS/MS analysis Rattus norvegicus 19 ALA5223084 organism-based format Scientific Literature