Antimycobacterial activity against Mycobacterium bovis BCG ATCC 35734 assessed as inhibition of bacterial growth incubated for 5 days in 7H9 standard media by broth dilution method
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv M16-1 harboring V285A mutant assessed as inhibition of bacterial growth incubated for 7 days by broth dilution method
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv M16-3 harboring V684G mutant assessed as inhibition of bacterial growth incubated for 7 days by broth dilution method
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv M16-4 harboring V684A mutant assessed as inhibition of bacterial growth incubated for 7 days by broth dilution method
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv M16-5 harboring G253E mutant assessed as inhibition of bacterial growth incubated for 7 days by broth dilution method
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv M33-1 harboring V643M mutant assessed as inhibition of bacterial growth incubated for 7 days by broth dilution method
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv M47-1 harboring A700T mutant assessed as inhibition of bacterial growth incubated for 7 days by broth dilution method
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv M47-2 harboring I244F mutant assessed as inhibition of bacterial growth incubated for 7 days by broth dilution method
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv M47-3 harboring Ins710Q mutant assessed as inhibition of bacterial growth incubated for 7 days by broth dilution method
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv M47-4 harboring V681I mutant assessed as inhibition of bacterial growth incubated for 7 days by broth dilution method
Antimycobacterial activity against Mycobacterium bovis BCG B33-2 harboring F255L mutant assessed as inhibition of bacterial growth incubated for 5 days by broth dilution method
Antimycobacterial activity against Mycobacterium bovis BCG B47-2 harboring V681I mutant assessed as inhibition of bacterial growth incubated for 5 days by broth dilution method
Antimycobacterial activity against Mycobacterium bovis BCG B47-4 harboring F644L mutant assessed as inhibition of bacterial growth incubated for 5 days by broth dilution method
Inhibition of MmpL3 C1932G/F644L mutant in Mycobacterium bovis BCG B47-4 assessed as reduction in TDM level at 1XMIC90 treated for 1 hr followed by incubation with [14C]acetate for 1 to 3 hrs by thin layer chromatography
Inhibition of MmpL3 C1932G/F644L mutant in Mycobacterium bovis BCG B47-4 assessed as increase in TMM level at 1XMIC90 treated for 1 hr followed by incubation with [14C]acetate for 1 to 3 hrs by thin layer chromatography
Disruption of proton motive force in Mycobacterium bovis BCG ATCC 35734 assessed as loss in mitochondrial membrane potential by measuring decline in fluorescence ratio at 4XMIC90 measured after >=12 hrs by DiOC2 based fluorescence analysis
Disruption of proton motive force in Mycobacterium smegmatis spheroplasts assessed as disruption of proton gradient by measuring acidification of intracellular spaces within spheroplasts at 2XMIC90 measured after 30 mins by BCECF-AM dye based fluorescence analysis