| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5248861 | T | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 40 uM measured after 24 hrs by MTT assay relative to control | Mus musculus | 33 | cell-based format | Scientific Literature | ||
| 2. | ALA5248862 | F | Anti inflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production at 2.5 uM preincubated with compound for 2 hrs followed by LPS stimulation and measured after 24 hrs by griess reagent based assay relative to control | Mus musculus | 18 | cell-based format | Scientific Literature | ||
| 3. | ALA5248863 | F | Anti inflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production at 5 uM preincubated with compound for 2 hrs followed by LPS stimulation and measured after 24 hrs by griess reagent based assay relative to control | Mus musculus | 18 | cell-based format | Scientific Literature | ||
| 4. | ALA5248864 | F | Anti inflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production preincubated with compound for 2 hrs followed by LPS stimulation and measured after 24 hrs by griess reagent based assay | Mus musculus | 9 | cell-based format | Scientific Literature | ||
| 5. | ALA5248865 | B | Binding affinity to STING in mouse RAW264.7 cells assessed as thermal stabilization at 40 to 61 degree C at 20 uM incubated for 8 hrs by cellular thermal shift assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA5248866 | B | Binding affinity to STING in mouse RAW264.7 cells assessed as thermal stabilization at 46 degree C measured for 8 hrs by cellular thermal shift assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5248867 | F | Inhibition of STING protein expression in LPS-induced mouse RAW264.7 cells preincubated with compound for 2 hrs followed by LPS stimulation and measured after 6 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5248868 | B | Inhibition of TBK1 phosphorylation in LPS-induced mouse RAW264.7 cells preincubated with compound for 2 hrs followed by LPS stimulation and measured after 6 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5248869 | B | Inhibition of IRF3 phosphorylation in LPS-induced mouse RAW264.7 cells preincubated with compound for 2 hrs followed by LPS stimulation and measured after 6 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5248870 | B | Inhibition of p65 phosphorylation in LPS-induced mouse RAW264.7 cells preincubated with compound for 2 hrs followed by LPS stimulation and measured after 6 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5248871 | B | Inhibition of IkappaB phosphorylation in LPS-induced mouse RAW264.7 cells preincubated with compound for 2 hrs followed by LPS stimulation and measured after 6 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5248872 | F | Anti inflammatory activity in LPS-induced mouse RAW264.7 cells assessed as suppression of TNF-alpha levels at 0.5 to 2 uM preincubated with compound for 2 hrs followed by LPS stimulation for 6 hrs by ELISA method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5248873 | F | Anti inflammatory activity in LPS-induced mouse RAW264.7 cells assessed as suppression of IL-6 levels at 0.5 to 2 uM preincubated with compound for 2 hrs followed by LPS stimulation for 6 hrs by ELISA method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5248874 | F | Anti inflammatory activity in LPS-induced mouse RAW264.7 cells assessed as suppression of IFN- beta levels at 0.5 to 2 uM preincubated with compound for 2 hrs followed by LPS stimulation for 6 hrs by ELISA method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5248875 | F | Protective activity against LPS induced sepsis in BALB/c mouse model of acute liver injury assessed as improvement of disorderly arranged liver tissue at 1.25 to 5 mg/kg, IG administered once a day for 3 days followed by LPS stimulation for 12 hrs starting from 2 hrs post last dose by hematoxylin and eosin staining based analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5248876 | F | Protective activity against LPS induced sepsis in BALB/c mouse model of acute liver injury assessed as improvement in blurred boundaries in liver tissue at 1.25 to 5 mg/kg, IG administered once a day for 3 days followed by LPS stimulation for 12 hrs starting from 2 hrs post last dose by hematoxylin and eosin staining based analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5248877 | F | Protective activity against LPS induced sepsis in BALB/c mouse model of acute liver injury assessed as improvement in swollen hepatocytes at 1.25 to 5 mg/kg, IG administered once a day for 3 days followed by LPS stimulation for 12 hrs starting from 2 hrs post last dose by hematoxylin and eosin staining based analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5248878 | F | Protective activity against LPS induced sepsis in BALB/c mouse model of acute liver injury assessed as reduction in necrotic hepatocytes at 1.25 to 5 mg/kg, IG administered once a day for 3 days followed by LPS stimulation for 12 hrs starting from 2 hrs post last dose by hematoxylin and eosin staining based analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5248879 | F | Protective activity against LPS induced sepsis in BALB/c mouse model of acute liver injury assessed as reduction in inflammatory cell infiltration at 1.25 to 5 mg/kg, IG administered once a day for 3 days followed by LPS stimulation for 12 hrs starting from 2 hrs post last dose by hematoxylin and eosin staining based analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5248880 | F | Protective activity against LPS induced sepsis in BALB/c mouse model of acute liver injury assessed as reduction in AST level in serum at 1.25 to 5 mg/kg, IG administered once a day for 3 days followed by LPS stimulation for 12 hrs starting from 2 hrs post last dose by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature |
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