| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5252384 | B | Inhibition of human Nav1.7/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput electrophysiology system analysis | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 2. | ALA5252385 | B | Inhibition of mouse Nav1.7/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput electrophysiology system analysis | Mus musculus | 24 | cell-based format | Scientific Literature | ||
| 3. | ALA5252387 | T | Inhibition of human Nav1.1/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput electrophysiology system analysis | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 4. | ALA5252388 | T | Inhibition of human Nav1.5/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput electrophysiology system analysis | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 5. | ALA5252391 | T | Inhibition of hERG at 100 uM | Homo sapiens | 19 | assay format | Scientific Literature | ||
| 6. | ALA5252392 | P | 1-Octanol/PBS buffer distribution coefficient, log D of the compound at pH 7.4 by HPLC/LC-MS analysis | 19 | small-molecule physicochemical format | Scientific Literature | |||
| 7. | ALA5252393 | P | Aqueous thermodynamic solubility of the compound at pH 6.8 measured after 4 hrs by HPLC-UV analysis | 19 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA5252394 | A | Unbound fraction in mouse plasma | Mus musculus | 19 | cell-free format | Scientific Literature | ||
| 9. | ALA5252395 | F | Analgesic activity against PSL-induced neuropathic pain mouse model assessed as reversal of thermal hyperalgesia at 1 mg/kg, po measured after 30 mins by plantar test | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 10. | ALA5252399 | A | Cmax in ddY mouse at 1 mg/kg, po by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 11. | ALA5252400 | A | Tmax in ddY mouse at 1 mg/kg, po by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 12. | ALA5252401 | A | AUC(0 to 24 hrs) in ddY mouse at 1 mg/kg, po by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 13. | ALA5252402 | A | Half life in ddY mouse at 1 mg/kg, po by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 14. | ALA5252403 | A | Total body clearance in ddY mouse at 1 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 15. | ALA5252404 | A | Volume of distribution at steady state in ddY mouse at 1 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA5252405 | A | Bioavailability in ddY mouse at 1 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA5252406 | U | Ratio of fCmax in ddY mouse plasma at 1 mg/kg, po to IC50 for inhibition of mouse Nav1.7/beta1/2 transfected in HEK293-A cells | 3 | organism-based format | Scientific Literature |
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