# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5258344 | B | Inhibition of recombinant N-terminal His-Avi-tag human FGFR3 (447 to 761 residues) expressed in Sf9 infected baculovirus expression system using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr in presence of ATP by HTRF assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
2. | ALA5258345 | B | Inhibition of recombinant human wild type FGFR1 (399 to 820 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr in presence of ATP by HTRF assay | Homo sapiens | 18 | single protein format | Scientific Literature | ||
3. | ALA5258347 | B | Inhibition of recombinant human FGFR4 (460 to 802 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr in presence of ATP by HTRF assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
4. | ALA5258348 | B | Inhibition of recombinant human FGFR2 (400 to 821 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr in presence of ATP by HTRF assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
5. | ALA5258349 | B | Inhibition of recombinant human ALK2 (147 to end residues) expressed in Sf9 infected baculovirus expression system using TRF0130 as substrate incubated for 3 hrs in presence of APT | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA5258350 | B | Inhibition of recombinant N-terminal His-tagged human FGFR3 V555L mutant using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr in presence of ATP by HTRF assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
7. | ALA5258351 | B | Inhibition of FGFR3 phosphorylation in mouse BaF3 cells incubated for 2 hrs | Mus musculus | 2 | cell-based format | Scientific Literature | ||
8. | ALA5258352 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 1 uM preincubated for 2 mins followed by NADPH addition and measured upto 30 mins by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
9. | ALA5258353 | A | Permeability in human Caco-2 cells incubated for 120 mins by LC-MS/MS analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA5258354 | A | Protein binding in human plasma assessed as free fraction after 2 hrs by equilibrium dialysis method | Homo sapiens | 2 | cell-free format | Scientific Literature | ||
11. | ALA5258355 | B | Inhibition of FGFR2 in human KATOIII cells incubated for 1 hr | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA5258356 | B | Inhibition of ERK phosphorylation in human RT112/84 cells whole blood incubated for 2 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA5258357 | A | Solubility of compound in fasted state stimulated intestinal fluid | 1 | assay format | Scientific Literature | |||
14. | ALA5258358 | A | Solubility of compound in stimulated gastric fluid | 1 | assay format | Scientific Literature | |||
15. | ALA5258359 | T | Inhibition of human ERG at 10 uM relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
16. | ALA5258360 | A | Cmax in Sprague-Dawley rat at 3 mg/kg, po measured up to 24 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
17. | ALA5258361 | A | AUCinfinity in Sprague-Dawley rat at 3 mg/kg, po measured up to 24 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
18. | ALA5258362 | A | Half life in Sprague-Dawley rat at 3 mg/kg, po or 1 mg/kg, iv measured up to 24 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
19. | ALA5258363 | A | Volume of distribution at steady state in Sprague-Dawley rat at 3 mg/kg, po or 1 mg/kg, iv measured up to 24 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
20. | ALA5258364 | A | Clearance in Sprague-Dawley rat at 3 mg/kg, po or 1 mg/kg, iv measured up to 24 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature |