| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5259064 | B | Partial agonist activity at N-terminal FLAG tagged/C-terminal NanoLuc tagged human muscarinic M1 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 2. | ALA5259065 | B | Partial agonist activity at N-terminal FLAG tagged/C-terminal NanoLuc tagged human muscarinic M1 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation by measuring maximum efficacy preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 3. | ALA5259066 | B | Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 4. | ALA5259067 | B | Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation by measuring maximum efficacy preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 5. | ALA5259070 | B | Partial agonist activity at N-terminal FLAG tagged/C-terminal NanoLuc tagged human muscarinic M4 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 6. | ALA5259071 | B | Partial agonist activity at N-terminal FLAG tagged/C-terminal NanoLuc tagged human muscarinic M4 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation by measuring maximum efficacy preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 7. | ALA5259073 | B | Partial agonist activity at N-terminal FLAG tagged/C-terminal NanoLuc tagged human muscarinic M5 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation by measuring maximum efficacy preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 8. | ALA5259076 | B | Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M3 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation at 100 uM preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA5259078 | B | Partial agonist activity at N-terminal FLAG tagged/C-terminal NanoLuc tagged human muscarinic M5 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation at 100 uM preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay | Homo sapiens | 4 | cell-based format | Scientific Literature |
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