| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5224086 | B | Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in Trichoplusia ni insect cells assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 30 mins followed by ATP addition and further incubated for 15 mins by ADP-Glo reagent based assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 2. | ALA5224087 | B | Inhibition of recombinant GST-tagged human Eg5 assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 30 mins followed by ATP addition and further incubated for 15 mins by ADP-Glo reagent based assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 3. | ALA5224088 | B | Inhibition of recombinant GST-tagged human CENP-E assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 30 mins followed by ATP addition and further incubated for 15 mins by ADP-Glo reagent based assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 4. | ALA5224089 | F | Induction of mitotic arrest in TP53 mutant human MDA-MB-157 cells assessed as multipolar spindle arrays by measuring pericentriolar material incubated for 24 hrs by mitotic index assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA5224090 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance at 0.5 uM incubated upto 40 mins by LCMS analysis | Mus musculus | 23 | microsome format | Scientific Literature | ||
| 6. | ALA5224091 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 0.5 uM incubated upto 40 mins by LCMS analysis | Homo sapiens | 23 | microsome format | Scientific Literature | ||
| 7. | ALA5224092 | F | Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 8. | ALA5224093 | F | Antiproliferative activity against human OVCAR-3 cells by nuclear count assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 9. | ALA5224096 | A | Clearance in CD-1 mouse at 1 mg/kg, iv and 10 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 10. | ALA5224097 | A | Volume of distribution at steady state in CD-1 mouse at 1 mg/kg, iv and 10 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 11. | ALA5224098 | A | Half life in CD-1 mouse at 1 mg/kg, iv and 10 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 12. | ALA5224099 | A | Cmax in CD-1 mouse at 1 mg/kg, iv and 10 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 13. | ALA5224100 | A | Oral bioavailability in CD-1 mouse at 10 mg/kg | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 14. | ALA5224101 | A | Unbound fraction in plasma (unknown origin) by ultracentrifugation | Not specified | 3 | cell-free format | Scientific Literature | ||
| 15. | ALA5224102 | A | Plasma concentration in CD-1 mouse at 100 mg/kg, po measured after 24 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5224103 | F | Antimitotic activity in human OVCAR-3 cells xenografted in CD-1 mouse assessed as increase in phospho-histone H3 positive cells in tumor at 100 mg/kg, po measured after 8 hrs | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5224104 | A | Plasma concentration in CD-1 mouse xenografted with human OVCAR-3 cells at 100 mg/kg, po measured after 8 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5224105 | A | Drug uptake in CD-1 mouse xenografted with human OVCAR-3 cells measured in tumor at 100 mg/kg, po measured after 8 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5224106 | F | Antimitotic activity in human OVCAR-3 cells xenografted in CD-1 mouse assessed as increase in phospho-histone H3 positive cells in tumor at 100 mg/kg, po measured after 24 hrs | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5224108 | F | Antimitotic activity in human OVCAR-3 cells xenografted in CD-1 mouse assessed as time prolongation of mitotic arrest per day at 100 mg/kg, po | Homo sapiens | 1 | organism-based format | Scientific Literature |
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