| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5239207 | B | Inhibition of bacterial VIM-1 (unknown origin) expressed in Escherichia coli EXPRESS BL21(DE3) assessed as inhibition constant by measuring rate of substrate hydrolysis by UV-visible spectrophotometry | Bacteria | 38 | assay format | Scientific Literature | ||
| 2. | ALA5239208 | B | Inhibition of bacterial VIM-2 (unknown origin) expressed in Escherichia coli EXPRESS BL21(DE3) assessed as inhibition constant by measuring rate of substrate hydrolysis by UV-visible spectrophotometry | Bacteria | 29 | assay format | Scientific Literature | ||
| 3. | ALA5239209 | B | Inhibition of bacterial VIM-4 (unknown origin) expressed in Escherichia coli EXPRESS BL21(DE3) assessed as inhibition constant by measuring rate of substrate hydrolysis by UV-visible spectrophotometry | Bacteria | 33 | assay format | Scientific Literature | ||
| 4. | ALA5239210 | B | Inhibition of bacterial NDM-1 (unknown origin) expressed in Escherichia coli EXPRESS BL21(DE3) assessed as inhibition constant by measuring rate of substrate hydrolysis by UV-visible spectrophotometry | Bacteria | 26 | assay format | Scientific Literature | ||
| 5. | ALA5239211 | B | Inhibition of bacterial IMP-1 (unknown origin) expressed in Escherichia coli EXPRESS BL21(DE3) assessed as inhibition constant by measuring rate of substrate hydrolysis by UV-visible spectrophotometry | Bacteria | 7 | assay format | Scientific Literature | ||
| 6. | ALA5239233 | F | Antimicrobial activity against blaVIM-1-producing multidrug-resistant Klebsiella pneumoniae K47-25 clinical isolate assessed as meropenem MIC at 32 ug/ml by broth microdilution method (Rvb = 16 ug/ml) | Klebsiella pneumoniae | 30 | organism-based format | Scientific Literature | ||
| 7. | ALA5239234 | F | Antimicrobial activity against blaVIM-4-producing multidrug-resistant Klebsiella pneumoniae VA-416/02 clinical isolate assessed as meropenem MIC at 32 ug/ml by broth microdilution method (Rvb = 16 ug/ml) | Klebsiella pneumoniae | 30 | organism-based format | Scientific Literature | ||
| 8. | ALA5239235 | F | Antimicrobial activity against blaVIM-2-producing multidrug-resistant Pseudomonas aeruginosa VA-182/00 clinical isolate assessed as meropenem MIC at 32 ug/ml by broth microdilution method (Rvb = 128 ug/ml) | Pseudomonas aeruginosa | 30 | organism-based format | Scientific Literature | ||
| 9. | ALA5239236 | F | Antimicrobial activity against blaNDM-1-producing multidrug-resistant Escherichia coli SI-004 clinical isolate assessed as meropenem MIC at 32 ug/ml by broth microdilution method (Rvb = 64 ug/ml) | Pseudomonas aeruginosa | 30 | organism-based format | Scientific Literature | ||
| 10. | ALA5239258 | T | Cytotoxicity against human HeLa cells assessed as LDH release incubated for 24 hrs by membrane integrity assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA5239259 | P | Solubility in PBS pH 7.4 after 24 hrs by LC-MS/MS analysis | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA5239260 | P | n-Octanol/PBS partition coefficient, logD of the compound at pH 7.4 after 2 hrs by LC-MS/MS analysis | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 13. | ALA5239261 | A | Stability in mouse plasma assessed as half life at 37 degC | Mus musculus | 5 | cell-free format | Scientific Literature | ||
| 14. | ALA5239262 | A | Metabolic stability in CD-1 mouse microsomes assessed as half life at 37 degC by LC-MS/MS analysis | Mus musculus | 6 | microsome format | Scientific Literature | ||
| 15. | ALA5239263 | A | Metabolic stability in CD-1 mouse microsomes assessed as intrinsic clearance at 37 degC by LC-MS/MS analysis | Mus musculus | 5 | microsome format | Scientific Literature | ||
| 16. | ALA5239264 | A | Plasma protein binding in CD-1 mouse plasma measured after 4 hrs by LC-MS/MS analysis | Mus musculus | 5 | cell-free format | Scientific Literature | ||
| 17. | ALA5239265 | A | Metabolic stability in CD-1 mouse microsomes assessed as compound remaining after 40 mins LC-MS/MS analysis | Mus musculus | 5 | microsome format | Scientific Literature | ||
| 18. | ALA5239266 | B | Inhibition of recombinant human IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate measured after 45 mins by fluorescence assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 19. | ALA5239269 | B | Inhibition of porcine APN using fluorogenic substrate H-Leu-AMC measured for 1 hr | Sus scrofa | 3 | single protein format | Scientific Literature | ||
| 20. | ALA5239270 | B | Inhibition of recombinant mouse ERAAP using fluorogenic substrate H-Leu-AMC at 100 uM relative to control | Mus musculus | 5 | single protein format | Scientific Literature |
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