| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5255934 | B | Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) stably expressed in HEK293 cells assessed as glutamate/glycine induced increase in intracellular calcium level at 10 uM incubated for 30 mins followed by addition of glutamate/glycine by Ca2+ influx assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA5255935 | F | Neuroprotective activity in middle cerebral artery occlusion-induced C57BL/6 mouse model assessed as reduction in infarct volume at 2 mg/kg, sc incubated with compound for 2 hrs after reperfusion by TTC staining based assay relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 3. | ALA5255937 | F | Neuroprotective activity against glutamate-induced neurotoxicity in rat PC-12 cells assessed as survival rate at 0.1 uM by WST-8 assay (Rvb = 40.8+/-2.0%) | Rattus norvegicus | 40 | cell-based format | Scientific Literature | ||
| 4. | ALA5255938 | F | Neuroprotective activity against glutamate-induced neurotoxicity in rat PC-12 cells assessed as survival rate at 1 uM by WST-8 assay | Rattus norvegicus | 40 | cell-based format | Scientific Literature | ||
| 5. | ALA5255939 | F | Neuroprotective activity against glutamate-induced neurotoxicity in rat PC-12 cells assessed as survival rate at 10 uM by WST-8 assay | Rattus norvegicus | 40 | cell-based format | Scientific Literature | ||
| 6. | ALA5255940 | T | Cytotoxicity in rat PC-12 cells assessed as reduction in cell viability at 10 uM incubated for 24 hrs by CCK-8 method | Rattus norvegicus | 40 | cell-based format | Scientific Literature | ||
| 7. | ALA5255941 | P | Solubility of the compound in water by UV spectophotometry analysis | 9 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA5255943 | B | Positive allosteric modulation of GluN1/GluN2B receptor (unknown origin) stably expressed in HEK293 cells assessed as glutamate/glycine induced increase in intracellular calcium level at 10 uM incubated for 30 mins followed by addition of glutamate/glycine by Ca2+ influx assay | Homo sapiens | 4 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!