# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5242438 | Binding | Inhibition of human MCT4 in human MDA-MB-231 cells assessed as inhibition of lactate efflux preincubated for 30 mins followed by D(+)glucose and measured after 4 hrs by dialysis based UHPLC-ESI-Q-Orbitrap-MS analysis | Homo sapiens | 73 | ALA5241094 | cell-based format | Scientific Literature | |
2. | ALA5242439 | Functional | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in intracellular lactate accumulation preincubated for 30 mins followed by D(+)glucose and measured after 4 hrs by UHPLC-ESI-Q-Orbitrap-MS analysis | Homo sapiens | 4 | ALA5241094 | cell-based format | Scientific Literature | |
3. | ALA5242440 | Functional | Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 6 days by MTS assay | Homo sapiens | 4 | ALA5241094 | cell-based format | Scientific Literature | |
4. | ALA5242441 | ADME | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance measured per mg of protein | Mus musculus | 19 | ALA5241094 | microsome format | Scientific Literature | |
5. | ALA5242453 | Binding | Inhibition of human MCT4 in human MDA-MB-231 cells assessed as inhibition of radioactive lactate efflux preincubated for 30 mins followed by D(+)glucose and measured after 4 hrs by dialysis based UHPLC-ESI-Q-Orbitrap-MS analysis | Homo sapiens | 5 | ALA5241094 | cell-based format | Scientific Literature | |
6. | ALA5242454 | Binding | Inhibition of human MCT4 in human SNU-398 cells assessed as inhibition of radioactive lactate efflux preincubated for 30 mins followed by D(+)glucose and measured after 4 hrs by dialysis based UHPLC-ESI-Q-Orbitrap-MS analysis | Homo sapiens | 5 | ALA5241094 | cell-based format | Scientific Literature | |
7. | ALA5242455 | Binding | Inhibition of human MCT4 in human SNU-398 cells assessed as inhibition of lactate efflux preincubated for 30 mins followed by D(+)glucose and measured after 4 hrs by dialysis based UHPLC-ESI-Q-Orbitrap-MS analysis | Homo sapiens | 6 | ALA5241094 | cell-based format | Scientific Literature |