# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5238129 | F | Potency index, ratio of PD IC50 to test compound IC50 for antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation by MTT assay | Homo sapiens | 3 | ALA5236586 | cell-based format | Scientific Literature | |
2. | ALA5238132 | F | Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation by MTT assay | Homo sapiens | 27 | ALA5236586 | cell-based format | Scientific Literature | |
3. | ALA5238133 | F | Antiproliferative activity against human PC-3 cells assessed as inhibition of cell proliferation by MTT assay | Homo sapiens | 27 | ALA5236586 | cell-based format | Scientific Literature | |
4. | ALA5238134 | F | Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation by MTT assay | Homo sapiens | 27 | ALA5236586 | cell-based format | Scientific Literature | |
5. | ALA5238135 | T | Cytotoxicity against mouse L929 cells assessed as inhibition of cell proliferation by MTT assay | Mus musculus | 27 | ALA5236586 | cell-based format | Scientific Literature | |
6. | ALA5238136 | F | Effect on cell morphology in human HepG2 cells assessed as cell shrinkage at 1.25 to 5 uM by DAPI staining based analysis | Homo sapiens | 1 | ALA5236586 | cell-based format | Scientific Literature | |
7. | ALA5238137 | F | Induction of apoptosis in human HepG2 cells at 1.25 to 5 uM by DAPI staining based analysis | Homo sapiens | 1 | ALA5236586 | cell-based format | Scientific Literature | |
8. | ALA5238139 | B | Inhibition of MDM2 in human HepG2 cells assessed as decrease in MDM2 protein level at 1.25 to 5 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA5236586 | cell-based format | Scientific Literature | |
9. | ALA5238140 | B | Inhibition of MDM2 in human HepG2 cells assessed as increase in p53 protein level at 1.25 to 5 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA5236586 | cell-based format | Scientific Literature | |
10. | ALA5238141 | F | Induction of apoptosis in human HepG2 cells assessed as increase in cleaved PARP level at 1.25 to 5 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA5236586 | cell-based format | Scientific Literature | |
11. | ALA5238142 | F | Induction of apoptosis in human HepG2 cells assessed as increase in Bax level at 1.25 to 5 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA5236586 | cell-based format | Scientific Literature | |
12. | ALA5238143 | F | Induction of apoptosis in human HepG2 cells assessed as increase in cleaved caspase-3 level at 1.25 to 5 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA5236586 | cell-based format | Scientific Literature | |
13. | ALA5238144 | F | Induction of apoptosis in human HepG2 cells assessed as decrease in Bcl-2 expression level at 1.25 to 5 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA5236586 | cell-based format | Scientific Literature | |
14. | ALA5238145 | F | Induction of apoptosis in human HepG2 cells assessed as decrease in caspase-3 expression level at 1.25 to 5 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA5236586 | cell-based format | Scientific Literature |