| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5252744 | B | Inhibition of human recombinant GST-fused VEGFR3 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mins in presence of gamma-[33P]-ATP by scintillation counting analysis | Homo sapiens | 9 | ALA5252510 | assay format | Scientific Literature | |
| 2. | ALA5252745 | B | Inhibition of human recombinant GST-fused VEGFR1 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mins in presence of gamma-[33P]-ATP by scintillation counting analysis | Homo sapiens | 9 | ALA5252510 | assay format | Scientific Literature | |
| 3. | ALA5252746 | B | Inhibition of mouse recombinant GST-fused VEGFR2 kinase domain expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mins in presence of gamma-[33P]-ATP by scintillation counting analysis | Mus musculus | 8 | ALA5252510 | assay format | Scientific Literature | |
| 4. | ALA5252747 | B | Inhibition of VEGF-induced human VEGFR2 autophosphorylation transfected in CHO cells measured after 2 hrs by chemiluminescence assay | Homo sapiens | 14 | ALA5252510 | cell-based format | Scientific Literature | |
| 5. | ALA5252748 | B | Inhibition of human recombinant GST-fused VEGFR2 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mins in presence of gamma-[33P]-ATP by scintillation counting analysis | Homo sapiens | 16 | ALA5252510 | assay format | Scientific Literature | |
| 6. | ALA5252758 | B | Selectivity ratio of IC50 for mouse VEGFR2 to IC50 for human VEGFR2 | 5 | ALA5252510 | assay format | Scientific Literature | ||
| 7. | ALA5252762 | A | Half-life in Sprague-Dawley rat at 3 mg/kg, iv measured upto 24 hrs by HPLC/UV analysis | Rattus norvegicus | 3 | ALA5252510 | organism-based format | Scientific Literature | |
| 8. | ALA5252763 | A | Volume of distribution at steady state in Sprague-Dawley rat at 3 mg/kg, iv measured upto 24 hrs by HPLC/UV analysis | Rattus norvegicus | 3 | ALA5252510 | organism-based format | Scientific Literature | |
| 9. | ALA5252764 | A | Clearance in Sprague-Dawley rat at 3 mg/kg, iv measured upto 24 hrs by HPLC/UV analysis | Rattus norvegicus | 3 | ALA5252510 | organism-based format | Scientific Literature | |
| 10. | ALA5252768 | T | Toxicity in C57BL/6jNpa mouse harbouring mouse B16-BL6 cells assessed as effect on animal behavior at 3 mg/kg, po qd administered started on day 7 post implantation measured after 21 days | Mus musculus | 5 | ALA5252510 | organism-based format | Scientific Literature | |
| 11. | ALA5252769 | T | Toxicity in C57BL/6jNpa mouse harbouring mouse B16-BL6 cells assessed as effect on animal well-being at 3 mg/kg, po qd administered started on day 7 post implantation measured after 21 days | Mus musculus | 5 | ALA5252510 | organism-based format | Scientific Literature | |
| 12. | ALA5252770 | T | Toxicity in C57BL/6jNpa mouse harbouring mouse B16-BL6 cells assessed as drug tolerability at 3 mg/kg, po qd administered started on day 7 post implantation measured after 21 days | Mus musculus | 5 | ALA5252510 | organism-based format | Scientific Literature | |
| 13. | ALA5252776 | B | Inhibition of VEGF-induced human VEGFR2 autophosphorylation expressed in HUVEC cells measured after 2 hrs by chemiluminescence assay | Homo sapiens | 6 | ALA5252510 | cell-based format | Scientific Literature | |
| 14. | ALA5252785 | F | Antiproliferative activity against mouse BaF3 cells expressing Tel-KDR-myc1.3 assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay | Mus musculus | 9 | ALA5252510 | cell-based format | Scientific Literature | |
| 15. | ALA5252786 | F | Antiproliferative activity against mouse BaF3 cells expressing Bcr-ABL assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay | Mus musculus | 9 | ALA5252510 | cell-based format | Scientific Literature | |
| 16. | ALA5252787 | F | Antiproliferative activity against mouse BaF3 cells expressing ERBB2 V659E mutant assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay | Mus musculus | 9 | ALA5252510 | cell-based format | Scientific Literature | |
| 17. | ALA5252788 | F | Antiproliferative activity against mouse BaF3 cells expressing Tel-FGFR3 assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay | Mus musculus | 9 | ALA5252510 | cell-based format | Scientific Literature | |
| 18. | ALA5252789 | F | Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay | Mus musculus | 9 | ALA5252510 | cell-based format | Scientific Literature | |
| 19. | ALA5252790 | F | Antiproliferative activity against mouse BaF3 cells expressing Tel-IGF-1R assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay | Mus musculus | 9 | ALA5252510 | cell-based format | Scientific Literature | |
| 20. | ALA5252791 | F | Antiproliferative activity against mouse BaF3 cells expressing KIT D816V mutant assessed as cell growth inhibition measured after 72 hrs by Alamar Blue assay | Mus musculus | 9 | ALA5252510 | cell-based format | Scientific Literature |
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