# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5232795 | B | Inhibition of NRF2/ARE (unknown origin) transfected in human MCF7 cells assessed as cellular activity preincubated with compound for 1 hrs followed by tBHQ addition and measured after 24 hrs by steady-glo luciferase assay relative to control | Homo sapiens | 39 | ALA5230161 | cell-based format | Scientific Literature | |
2. | ALA5232797 | P | Solubility of the compound in pH 7.4 PBS buffer | 4 | ALA5230161 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA5232798 | F | Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 4 | ALA5230161 | cell-based format | Scientific Literature | |
4. | ALA5232799 | B | Inhibition of NRF2 signalling pathway in human A549 cells assessed as decrease in NRF2 protein level at 5 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA5230161 | cell-based format | Scientific Literature | |
5. | ALA5232800 | B | Inhibition of NRF2 signalling pathway in human NCI-H460 cells assessed as decrease in NRF2 protein level at 5 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA5230161 | cell-based format | Scientific Literature | |
6. | ALA5232805 | B | Inhibition of NRF2 signalling pathway in human A549 cells assessed as decrease in NQO1 mRNA level at 10 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA5230161 | cell-based format | Scientific Literature | |
7. | ALA5232806 | B | Inhibition of NRF2 signalling pathway in human A549 cells assessed as decrease in GCLC mRNA level at 10 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA5230161 | cell-based format | Scientific Literature | |
8. | ALA5232807 | B | Inhibition of NRF2 signalling pathway in human A549 cells assessed as decrease in AKR1C2 mRNA level at 10 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA5230161 | cell-based format | Scientific Literature | |
9. | ALA5232808 | B | Inhibition of NRF2 signalling pathway in human A549 cells assessed as decrease in GCLM mRNA level at 10 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA5230161 | cell-based format | Scientific Literature | |
10. | ALA5232812 | F | Induction of cell cycle arrest in human A549 cells assessed as accumulation of cells at G2/M phase at 10 uM incubated for 24 hrs by PI staining based flow cytometric analysis | Homo sapiens | 1 | ALA5230161 | cell-based format | Scientific Literature | |
11. | ALA5232815 | F | Induction of cell cycle arrest in human NCI-H460 cells assessed as accumulation of cells at G2/M phase at 10 uM incubated for 24 hrs by PI staining based flow cytometric analysis | Homo sapiens | 1 | ALA5230161 | cell-based format | Scientific Literature | |
12. | ALA5232817 | F | Inhibition of cell migration in human A549 cells at 10 uM incubated for 24 hrs by DAPI staining based transwell migration assay relative to control | Homo sapiens | 2 | ALA5230161 | cell-based format | Scientific Literature | |
13. | ALA5232821 | F | Synergistic antiproliferative activity against human A549 cells assessed as combination index measured after 72 hrs in the presence of carboplatin by celltiter-glo assay | Homo sapiens | 1 | ALA5230161 | cell-based format | Scientific Literature | |
14. | ALA5232822 | F | Synergistic antiproliferative activity against human A549 cells assessed as combination index measured after 72 hrs in the presence of 5-fluorouracil by celltiter-glo assay | Homo sapiens | 1 | ALA5230161 | cell-based format | Scientific Literature |