| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5243964 | B | Inhibition of AURKA in human RPE-MYC H2B-GFP cells assessed as inhibition of autophosphorylation of AURKA at Thr288 residue by measuring residual enzyme activity at 10 uM measured after 6 hrs by immunofluorescence staining analysis (Rvb = 100 +/-1%) | Homo sapiens | 1 | ALA5241130 | cell-based format | Scientific Literature | |
| 2. | ALA5243965 | B | Inhibition of AURKA in human RPE-MYC H2B-GFP cells assessed as inhibition of autophosphorylation of AURKA at Thr288 residue by measuring residual enzyme activity at 20 uM measured after 6 hrs by immunofluorescence staining analysis (Rvb = 100 +/-1%) | Homo sapiens | 1 | ALA5241130 | cell-based format | Scientific Literature | |
| 3. | ALA5243966 | B | Inhibition of AURKA in human RPE-MYC H2B-GFP cells assessed as inhibition of autophosphorylation of AURKA at Thr288 residue by measuring residual enzyme activity at 40 uM measured after 6 hrs by immunofluorescence staining analysis (Rvb = 100+/-1%) | Homo sapiens | 1 | ALA5241130 | cell-based format | Scientific Literature | |
| 4. | ALA5243970 | B | Inhibition of AURKB in human RPE-MYC H2B-GFP cells assessed as inhibition of histone H3 phosphorylation at Ser10 residue by measuring residual enzyme activity at 10 uM measured after 6 hrs by immunofluorescence staining analysis (Rvb = 100 +/-9%) | Homo sapiens | 1 | ALA5241130 | cell-based format | Scientific Literature | |
| 5. | ALA5243971 | B | Inhibition of AURKB in human RPE-MYC H2B-GFP cells assessed as inhibition of histone H3 phosphorylation at Ser10 residue by measuring residual enzyme activity at 20 uM measured after 6 hrs by immunofluorescence staining analysis (Rvb = 100 +/-9%) | Homo sapiens | 1 | ALA5241130 | cell-based format | Scientific Literature | |
| 6. | ALA5243972 | B | Inhibition of AURKB in human RPE-MYC H2B-GFP cells assessed as inhibition of histone H3 phosphorylation at Ser10 residue by measuring residual enzyme activity at 40 uM measured after 6 hrs by immunofluorescence staining analysis (Rvb = 100 +/-9%) | Homo sapiens | 1 | ALA5241130 | cell-based format | Scientific Literature | |
| 7. | ALA5243976 | B | Disruption of mitotic localization of AURKB in human RPE-MYC H2B-GFP cells assessed as proportion of polyploid cells in fully attached cell population at 10 uM measured after 72 hrs by fluorescence high content cell imaging analysis (Rvb <1%) | Homo sapiens | 1 | ALA5241130 | cell-based format | Scientific Literature | |
| 8. | ALA5243977 | B | Disruption of mitotic localization of AURKB in human RPE-MYC H2B-GFP cells assessed as proportion of polyploid cells in fully attached cell population at 20 uM measured after 72 hrs by fluorescence high content cell imaging analysis (Rvb <1%) | Homo sapiens | 1 | ALA5241130 | cell-based format | Scientific Literature | |
| 9. | ALA5243978 | B | Disruption of mitotic localization of AURKB in human RPE-MYC H2B-GFP cells assessed as proportion of polyploid cells in fully attached cell population at 40 uM measured after 72 hrs by fluorescence high content cell imaging analysis (Rvb <1%) | Homo sapiens | 1 | ALA5241130 | cell-based format | Scientific Literature | |
| 10. | ALA5243982 | B | Disruption of mitotic localization of AURKB in human RPE-MYC H2B-GFP cells assessed as mitotic index at 10 uM measured after 6 hrs by fluorescence high content cell imaging analysis (Rvb = 4.7+/-0.4%) | Homo sapiens | 1 | ALA5241130 | cell-based format | Scientific Literature | |
| 11. | ALA5243983 | B | Disruption of mitotic localization of AURKB in human RPE-MYC H2B-GFP cells assessed as mitotic index at 20 uM measured after 6 hrs by fluorescence high content cell imaging analysis (Rvb = 4.7+/-0.4%) | Homo sapiens | 1 | ALA5241130 | cell-based format | Scientific Literature | |
| 12. | ALA5243984 | B | Disruption of mitotic localization of AURKB in human RPE-MYC H2B-GFP cells assessed as mitotic index at 40 uM measured after 6 hrs by fluorescence high content cell imaging analysis (Rvb = 4.7+/-0.4%) | Homo sapiens | 1 | ALA5241130 | cell-based format | Scientific Literature | |
| 13. | ALA5243986 | B | Disruption of mitotic localization of AURKB in human RPE-MYC H2B-GFP cells assessed as induction of mitotic arrest measured after 24 hrs by fluorescence high content cell imaging analysis | Homo sapiens | 32 | ALA5241130 | cell-based format | Scientific Literature | |
| 14. | ALA5243987 | B | Disruption of mitotic localization of AURKB in human RPE-MYC H2B-GFP cells assessed as induction of polyploidy by fluorescence high content cell imaging analysis | Homo sapiens | 32 | ALA5241130 | cell-based format | Scientific Literature |
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