# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5232370 | Toxicity | Cytotoxicity against human HEK293 cells assessed as cell viability measured by Cell titre glo assay | Homo sapiens | 21 | ALA5230148 | cell-based format | Scientific Literature | |
2. | ALA5232371 | Binding | Inhibition of human CFTR F508 deletion mutant ubiquitination expressed in human HEK293 cells assessed as inhibition of binding of 25I-ubiquitin in presence of ATP at 300 uM measured by radiography method relative to PYR-41 | Homo sapiens | 2 | ALA5230148 | cell-based format | Scientific Literature | |
3. | ALA5232372 | Binding | Inhibition of human CFTR ubiquitination in human HEK293 cells assessed as inhibition of binding of 25I-ubiquitin in presence of ATP at 300 uM measured by radiography method relative to PYR-41 | Homo sapiens | 2 | ALA5230148 | cell-based format | Scientific Literature | |
4. | ALA5232373 | Binding | Inhibition of yeast CFTR ubiquitination assessed as inhibition of binding of 25I-ubiquitin in presence of ATP at 300 uM measured by radiography method relative to PYR-41 | Saccharomyces cerevisiae | 2 | ALA5230148 | assay format | Scientific Literature | |
5. | ALA5232375 | Binding | Induction of stabilisation of human CFTR F508 deletion mutant expressed in human HEK293 cells assessed as VX-809-dependent maturation by measuring banc C at 10 uM measured after 24 hrs by Western blotting assay | Homo sapiens | 2 | ALA5230148 | cell-based format | Scientific Literature | |
6. | ALA5232376 | Binding | Induction of stabilisation of human CFTR F508 deletion mutant expressed in human CFBE41o- cells assessed as VX-809-dependent maturation by measuring banc C at 10 uM measured after 24 hrs by western blotting assay relative to VX-809 | Homo sapiens | 1 | ALA5230148 | cell-based format | Scientific Literature | |
7. | ALA5232377 | Binding | Induction of stabilisation of human CFTR F508 deletion mutant fused with FAP expressed in human HEK293 cells assessed as trafficking of CFTR to plasma membrane measured by western blotting assay | Homo sapiens | 2 | ALA5230148 | cell membrane format | Scientific Literature | |
8. | ALA5232378 | Binding | Induction of stabilisation of human CFTR F508 deletion mutant bound with FAP expressed in human HEK293 cells assessed as trafficking of CFTR to plasma membrane in presence of VX-809 measured by western blotting assay | Homo sapiens | 1 | ALA5230148 | cell membrane format | Scientific Literature |