| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5232370 | T | Cytotoxicity against human HEK293 cells assessed as cell viability measured by Cell titre glo assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 2. | ALA5232371 | B | Inhibition of human CFTR F508 deletion mutant ubiquitination expressed in human HEK293 cells assessed as inhibition of binding of 25I-ubiquitin in presence of ATP at 300 uM measured by radiography method relative to PYR-41 | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA5232372 | B | Inhibition of human CFTR ubiquitination in human HEK293 cells assessed as inhibition of binding of 25I-ubiquitin in presence of ATP at 300 uM measured by radiography method relative to PYR-41 | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA5232373 | B | Inhibition of yeast CFTR ubiquitination assessed as inhibition of binding of 25I-ubiquitin in presence of ATP at 300 uM measured by radiography method relative to PYR-41 | Saccharomyces cerevisiae | 2 | assay format | Scientific Literature | ||
| 5. | ALA5232375 | B | Induction of stabilisation of human CFTR F508 deletion mutant expressed in human HEK293 cells assessed as VX-809-dependent maturation by measuring banc C at 10 uM measured after 24 hrs by Western blotting assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA5232376 | B | Induction of stabilisation of human CFTR F508 deletion mutant expressed in human CFBE41o- cells assessed as VX-809-dependent maturation by measuring banc C at 10 uM measured after 24 hrs by western blotting assay relative to VX-809 | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5232377 | B | Induction of stabilisation of human CFTR F508 deletion mutant fused with FAP expressed in human HEK293 cells assessed as trafficking of CFTR to plasma membrane measured by western blotting assay | Homo sapiens | 2 | cell membrane format | Scientific Literature | ||
| 8. | ALA5232378 | B | Induction of stabilisation of human CFTR F508 deletion mutant bound with FAP expressed in human HEK293 cells assessed as trafficking of CFTR to plasma membrane in presence of VX-809 measured by western blotting assay | Homo sapiens | 1 | cell membrane format | Scientific Literature |
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