| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5251708 | B | Inhibition of P-gp efflux in vincristine resistant human Eca-109 cells assessed as increase in rhodamine 123 fluorescence intensity at 30 uM | Homo sapiens | 1 | ALA5247655 | cell-based format | Scientific Literature | |
| 2. | ALA5251709 | F | Cytotoxicity against vincristine resistant human Eca-109 cells incubated for 48 hrs by CCK-8 method relative to control | Homo sapiens | 43 | ALA5247655 | cell-based format | Scientific Literature | |
| 3. | ALA5251710 | F | Reversal of VCR -resistance in human Eca-109 cells assessed as vincristine IC50 by measuring cell viability incubated for 48 hrs by CCK-8 method (Rvb = 6830.0+/-537.0 nM) | Homo sapiens | 43 | ALA5247655 | cell-based format | Scientific Literature | |
| 4. | ALA5251711 | F | Reversal of vincristine-resistance in human Eca-109 cells assessed as fold reversal by measuring cell viability incubated for 48 hrs by CCK-8 method relative to vincristine alone | Homo sapiens | 43 | ALA5247655 | cell-based format | Scientific Literature | |
| 5. | ALA5251712 | P | Solubility of the compound in water at 25 degree C by shake flask method based UV-spectrophotometric method | 2 | ALA5247655 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA5251713 | F | Cytotoxicity against human Eca-109 cells incubated for 48 hrs by CCK-8 method | Homo sapiens | 1 | ALA5247655 | cell-based format | Scientific Literature | |
| 7. | ALA5251714 | F | Cytotoxicity against vincristine resistant human Eca-109 cells incubated for 48 hrs by CCK-8 method | Homo sapiens | 1 | ALA5247655 | cell-based format | Scientific Literature | |
| 8. | ALA5251715 | T | Cytotoxicity against human LX2 cells incubated for 48 hrs by CCK-8 method | Homo sapiens | 1 | ALA5247655 | cell-based format | Scientific Literature | |
| 9. | ALA5251716 | T | Cytotoxicity against HEK293T cells incubated for 48 hrs by CCK-8 method | Homo sapiens | 1 | ALA5247655 | cell-based format | Scientific Literature | |
| 10. | ALA5251717 | T | Cytotoxicity against human GES1 cells incubated for 48 hrs by CCK-8 method | Homo sapiens | 1 | ALA5247655 | cell-based format | Scientific Literature | |
| 11. | ALA5251718 | T | Cytotoxicity against human HK-2 cells incubated for 48 hrs by CCK-8 method | Homo sapiens | 1 | ALA5247655 | cell-based format | Scientific Literature | |
| 12. | ALA5251719 | F | Reversal of VCR -resistance in human Eca-109 cells assessed as cell viability at 1 uM incubated for 48 hrs by CCK-8 method (Rvb = 6830.0+/-537.0 nM) | Homo sapiens | 1 | ALA5247655 | cell-based format | Scientific Literature | |
| 13. | ALA5251720 | F | Reversal of VCR -resistance in human Eca-109 cells assessed as cell viability at 2.5 uM incubated for 48 hrs by CCK-8 method (Rvb = 6830.0+/-537.0 nM) | Homo sapiens | 1 | ALA5247655 | cell-based format | Scientific Literature | |
| 14. | ALA5251721 | F | Reversal of VCR -resistance in human Eca-109 cells assessed as cell viability at 5 uM incubated for 48 hrs by CCK-8 method (Rvb = 6830.0+/-537.0 nM) | Homo sapiens | 5 | ALA5247655 | cell-based format | Scientific Literature | |
| 15. | ALA5251722 | F | Reversal of vincristine-resistance in human Eca-109 cells assessed as fold reversal by measuring cell viability at 1 uM incubated for 48 hrs by CCK-8 method relative to vincristine alone | Homo sapiens | 1 | ALA5247655 | cell-based format | Scientific Literature | |
| 16. | ALA5251723 | F | Reversal of vincristine-resistance in human Eca-109 cells assessed as fold reversal by measuring cell viability at 2.5 uM incubated for 48 hrs by CCK-8 method relative to vincristine alone | Homo sapiens | 1 | ALA5247655 | cell-based format | Scientific Literature | |
| 17. | ALA5251724 | F | Reversal of vincristine-resistance in human Eca-109 cells assessed as fold reversal by measuring cell viability at 5 uM incubated for 48 hrs by CCK-8 method relative to vincristine alone | Homo sapiens | 5 | ALA5247655 | cell-based format | Scientific Literature | |
| 18. | ALA5251725 | F | Induction of apoptosis in vincristine resistant human Eca-109 cells assessed as viable cells at 1 uM incubated for 24 hrs by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb = 90.3%) | Homo sapiens | 1 | ALA5247655 | cell-based format | Scientific Literature | |
| 19. | ALA5251726 | F | Induction of apoptosis in vincristine resistant human Eca-109 cells assessed as viable cells at 2.5 uM incubated for 24 hrs by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb = 90.3%) | Homo sapiens | 1 | ALA5247655 | cell-based format | Scientific Literature | |
| 20. | ALA5251727 | F | Induction of apoptosis in vincristine resistant human Eca-109 cells assessed as viable cells at 5 uM incubated for 24 hrs by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb = 90.3%) | Homo sapiens | 3 | ALA5247655 | cell-based format | Scientific Literature |
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