| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5251238 | B | Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) at 1 uM incubated for 180 mins by competitive radioligand binding assay (Rvb = 1.3 %) | Homo sapiens | 24 | single protein format | Scientific Literature | ||
| 2. | ALA5251239 | B | Displacement of [3H]-U69593 from kappa opioid receptor (unknown origin) at 1 uM incubated for 180 mins by competitive radioligand binding assay (Rvb = 0.6 %) | Homo sapiens | 24 | single protein format | Scientific Literature | ||
| 3. | ALA5251240 | B | Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) at 10 uM incubated for 180 mins by competitive radioligand binding assay (Rvb = 1.9 %) | Homo sapiens | 24 | single protein format | Scientific Literature | ||
| 4. | ALA5251241 | B | Displacement of [3H]-U69593 from kappa opioid receptor (unknown origin) at 10 uM incubated for 180 mins by competitive radioligand binding assay (Rvb = 0.6 %) | Homo sapiens | 24 | single protein format | Scientific Literature | ||
| 5. | ALA5251242 | B | Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioligand binding assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 6. | ALA5251243 | B | Displacement of [3H]-U69593 from kappa opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioligand binding assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 7. | ALA5251244 | B | Selectivity ratio of Ki for kappa opioid receptor (unknown origin) to Ki for mu opioid receptor (unknown origin) | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 8. | ALA5251245 | B | Agonist activity at HA-tagged mouse mu opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by Glo Sensor assay | Mus musculus | 8 | cell-based format | Scientific Literature | ||
| 9. | ALA5251246 | B | Agonist activity at HA-tagged mouse mu opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by Glo Sensor assay relative to control | Mus musculus | 8 | cell-based format | Scientific Literature | ||
| 10. | ALA5251247 | B | Agonist activity at delta opioid receptor (unknown origin) expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by Glo Sensor assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5251248 | B | Agonist activity at delta opioid receptor (unknown origin) expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by Glo Sensor assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5251249 | B | Agonist activity at FLAG-tagged mouse kappa opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by Glo Sensor assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5251250 | B | Agonist activity at FLAG-tagged mouse kappa opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by Glo Sensor assay relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5251251 | B | Agonist activity at human mu opioid receptor expressed in CHO-K1 cells coexpressing beta-arrestin-2 assessed as increase in beta arrestin-2 recruitment at 10 uM by PathHunter assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5251252 | F | Antinociceptive activity in C57BL/6 mouse assessed as latency of rapid tail-flick response by measuring maximal possible effect at 10 to 100 mg/kg, sc and measured for 15 to 240 mins by warm-water tail-flick assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5251253 | F | Antinociceptive activity in C57BL/6 mouse assessed as latency of hind-paw response by measuring maximal possible effect at 10 to 100 mg/kg, sc and measured for 15 to 240 mins by hot-plate assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5251254 | F | Antinociceptive activity in C57BL/6 mouse assessed as latency of rapid tail-flick response at 100 mg/kg, sc pretreated with naloxone for 15mins followed by compound addition and measured for 30 to 240 mins by warm-water tail-flick assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5251255 | F | Antinociceptive activity in C57BL/6 mouse assessed as latency of hind-paw response at 100 mg/kg, sc pretreated with naloxone for 15mins followed by compound addition and measured for 30 to 240 mins by hot plate assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5251256 | F | Effect on locomotor activity in C57BL/6 mouse assessed as impaired motor activity by observing latency to fall at 65 to 80 mg/kg, sc and measured after 15 mins by rotorod test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5251257 | B | Agonist activity at human mu opioid receptor expressed in CHO-K1 cells cotransfected with Galpha-RLuc8:Gbeta:Ggamma-GFP assessed as Gi1 signaling pathway incubated for 5 mins by TRUPATH assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature |
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