# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5223630 | B | Binding affinity to human wild-type double stranded DNA assessed as thermal stability of compound-DNA complex by measuring change in melting temperature at stoichiometry ratio 1:0.5 by UV melting assay | Homo sapiens | 3 | nucleic acid format | Scientific Literature | ||
2. | ALA5223631 | B | Binding affinity to human wild-type double stranded DNA assessed as thermal stability of compound-DNA complex by measuring change in melting temperature at stoichiometry ratio 1:1 by UV melting assay | Homo sapiens | 3 | nucleic acid format | Scientific Literature | ||
3. | ALA5223632 | B | Binding affinity to human wild-type double stranded DNA assessed as thermal stability of compound-DNA complex by measuring change in melting temperature at stoichiometry ratio 1:4 by UV melting assay | Homo sapiens | 3 | nucleic acid format | Scientific Literature | ||
4. | ALA5223640 | B | Binding affinity to human single stranded DNA (unknown origin) by electrophoretic mobility shift assay | Not specified | 3 | assay format | Scientific Literature | ||
5. | ALA5223641 | B | Binding affinity to DNA STAT3 binding site of PD-L1 promoter region (unknown origin) by electrophoretic mobility shift assay | Not specified | 1 | assay format | Scientific Literature | ||
6. | ALA5223643 | B | Binding affinity to DNA STAT3 binding site of PD-L1 promoter region assessed as effect on binding of STAT3 protein to STAT3 binding site of PD-L1 promoter region by competitive electrophoretic mobility shift assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
7. | ALA5223648 | F | Inhibition of PD-L1 protein expression in IFNgamma-induced human HCC827 cells measured for 36 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
8. | ALA5223649 | F | Inhibition of PD-L1 protein expression in IFNgamma-induced human MDA-MB-231 cells measured for 36 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
9. | ALA5223651 | F | Induction of T-cell mediated cell killing in human HCC827 cells co-cultured with PMA-activated Jurkat T cells assessed as IL-2 production at 8 uM by ELISA relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
10. | ALA5223652 | F | Induction of T-cell mediated cell killing in human MDA-MB-231 cells co-cultured with PMA-activated Jurkat T cells assessed as IL-2 production at 8 uM by ELISA relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
11. | ALA5223653 | F | Induction of T-cell mediated cytotoxicity against human HCC827 cells co-cultured with Jurkat cells assessed as apoptotic cells at 8 uM incubated for 36 hrs by standard CCK-8 assay relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
12. | ALA5223654 | F | Induction of T-cell mediated cytotoxicity against human MDA-MB-231 cells co-cultured with Jurkat cells assessed as apoptotic cells at 8 uM incubated for 36 hrs by standard CCK-8 assay relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
13. | ALA5223655 | T | Cytotoxicity against human Jurkat cells at 8 uM incubated for 36 hrs by standard CCK-8 assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
14. | ALA5223656 | F | Cytotoxicity against human HCC827 cells incubated for 36 hrs by standard CCK-8 assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
15. | ALA5223657 | F | Cytotoxicity against human MDA-MB-231 cells incubated for 36 hrs by standard CCK-8 assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
16. | ALA5223658 | T | Cytotoxicity against human MRC5 cells at 32 uM by standard CCK-8 assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
17. | ALA5223667 | F | Antitumour activity against human MDA-MB-231 cells assessed as measuring interleukin-2 levels by ELISA | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
18. | ALA5223668 | F | Antitumour activity against human HCC827 cells assessed as measuring interleukin-2 levels by ELISA | Homo sapiens | 3 | cell-based format | Scientific Literature |