# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5248761 | B | Inhibition of N-terminal his-tagged human recombinant LSD1 at 10 uM using 10-acetyl-3,7-dihydroxyphenoxazine as substrate measured for 30 mins by multiplate reader analysis relative to control | Homo sapiens | 44 | ALA5247583 | single protein format | Scientific Literature | |
2. | ALA5248772 | B | Inhibition of LSD1 in human CHP-134 cells assessed as increase in H3K4me2 level at 0.037 uM measured for 72 hrs by DAPI staining based analysis relative to control | Homo sapiens | 1 | ALA5247583 | cell-based format | Scientific Literature | |
3. | ALA5248773 | B | Inhibition of LSD1 in human IMR-32 cells assessed as increase in H3K4me2 level at 0.333 uM measured for 72 hrs by DAPI staining based analysis relative to control | Homo sapiens | 2 | ALA5247583 | cell-based format | Scientific Literature | |
4. | ALA5248779 | F | Cytotoxicity against human CHP-134 cells assessed as lethal concentration measured after 24 hrs in presence of bortezomib by cell titer glo assay | Homo sapiens | 2 | ALA5247583 | cell-based format | Scientific Literature | |
5. | ALA5248781 | F | Cytotoxicity against human IMR-32 cells assessed as lethal concentration measured after 24 hrs in presence of bortezomib by cell titer glo assay | Homo sapiens | 2 | ALA5247583 | cell-based format | Scientific Literature | |
6. | ALA5248782 | F | Potency index, ratio of bortezomib IC50 to compound IC50 for cytotoxicity against human IMR-32 cells assessed as lethal concentration measured after 24 hrs by cell titer glo assay | Homo sapiens | 2 | ALA5247583 | cell-based format | Scientific Literature | |
7. | ALA5248784 | F | Cytotoxicity against human IMR-32 cells assessed as combination index measured after 24 hrs in presence of bortezomib by cell titer glo assay | Homo sapiens | 1 | ALA5247583 | cell-based format | Scientific Literature | |
8. | ALA5248785 | F | Cytotoxicity against human CHP-134 cells assessed as combination index measured after 24 hrs in presence of bortezomib by cell titer glo assay | Homo sapiens | 1 | ALA5247583 | cell-based format | Scientific Literature |