| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5252094 | B | Activation of cGAMP-STING signaling pathway in human THP-1 cells assessed as increase in ISRE activation by measuring luciferase activation at 5 uM in presence of 1 ug/ml cGAMP by luciferase reporter gene assay relative to control | Homo sapiens | 13 | ALA5247661 | cell-based format | Scientific Literature | |
| 2. | ALA5252095 | B | Activation of cGAMP-STING signaling pathway in human THP-1 cells assessed as increase in ISRE activation by measuring luciferase activation in presence of cGAMP by luciferase reporter gene assay | Homo sapiens | 3 | ALA5247661 | cell-based format | Scientific Literature | |
| 3. | ALA5252096 | B | Activation of STING in human THP-1 cells assessed as increase in ISRE activation at 3.125 to 50 uM by luciferase reporter gene assay | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 4. | ALA5252097 | B | Activation of cGAMP-STING signaling pathway in human THP-1 cells assessed as increase in ISRE activation in presence of 1 ug/ml cGAMP by luciferase reporter gene assay | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 5. | ALA5252098 | B | Activation of cGAMP-STING signaling pathway in wild type human THP-1 cells assessed as increase in ISRE activation at 3.125 to 50 uM in presence of 1 ug/ml cGAMP by luciferase reporter gene assay | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 6. | ALA5252099 | F | Activation of cGAMP-STING-mediated immunity in STING knock-out human THP-1 cells assessed as increase in ISRE activation at 3.125 to 50 uM in presence of 1 ug/ml cGAMP by luciferase reporter gene assay | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 7. | ALA5252100 | F | Activation of innate immune response in human THP-1 cells assessed as stimulation of type I IFN response by measuring increase in IP-10 secretion at 5 uM by ELISA | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 8. | ALA5252101 | F | Activation of innate immune response in human THP-1 cells assessed as stimulation of type I IFN response by measuring increase in IP-10 secretion at 5 uM in presence of 1 ug/ml cGAMP by ELISA | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 9. | ALA5252102 | T | Cytotoxicity against human THP-1 cells assessed as cell viability at 5 uM | Homo sapiens | 13 | ALA5247661 | cell-based format | Scientific Literature | |
| 10. | ALA5252103 | T | Cytotoxicity against human THP-1 cells assessed as effect on cell viability at 5 uM in presence of 1 ug/ml cGAMP | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 11. | ALA5252104 | B | Activation of cGAMP-STING signaling pathway in human THP-1 cells assessed as increase in STAT1 phosphorylation at 0.2 uM in presence of 20 ug/ml cGAMP by western blot analysis | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 12. | ALA5252105 | B | Activation of cGAMP-STING signaling pathway in human THP-1 cells assessed as increase in IRF3 phosphorylation at 0.2 uM in presence of 20 ug/ml cGAMP by western blot analysis | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 13. | ALA5252106 | B | Activation of STING in human THP-1 cells assessed as increase in IFN-beta mRNA expression at 2.5 uM | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 14. | ALA5252107 | B | Activation of STING in human THP-1 cells assessed as increase in CXCL10 mRNA expression at 2.5 uM | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 15. | ALA5252108 | B | Activation of STING in human THP-1 cells assessed as increase in OAS1 mRNA expression at 2.5 uM | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 16. | ALA5252109 | B | Activation of STING in human THP-1 cells assessed as increase in IFIT3 mRNA expression at 2.5 uM | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 17. | ALA5252110 | B | Activation of STING in human THP-1 cells assessed as increase in IL6 mRNA expression at 2.5 uM | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 18. | ALA5252111 | B | Activation of STING in human THP-1 cells assessed as increase in IFITM1 mRNA expression at 2.5 uM | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 19. | ALA5252112 | B | Activation of cGAMP-STING signaling pathway in human THP-1 cells assessed as increase in IFN-beta mRNA expression at 2.5 uM in presence of 1 ug/ml cGAMP | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature | |
| 20. | ALA5252113 | B | Activation of cGAMP-STING signaling pathway in human THP-1 cells assessed as increase in CXCL10 mRNA expression at 2.5 uM in presence of 1 ug/ml cGAMP | Homo sapiens | 1 | ALA5247661 | cell-based format | Scientific Literature |
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