| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5238069 | Binding | Inhibition of N-terminal GST-tagged human wild type ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus-infected Sf21 cells using LANCE Ultra ULight-PolyGT substrate at 100 nM incubated for 2 hrs by TR-FRET assay | Homo sapiens | 8 | ALA5236584 | cell-based format | Scientific Literature | |
| 2. | ALA5238070 | Binding | Inhibition of N-terminal GST-tagged human wild type ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus-infected Sf21 cells using LANCE Ultra ULight-PolyGT substrate incubated for 2 hrs by TR-FRET assay | Homo sapiens | 11 | ALA5236584 | cell-based format | Scientific Literature | |
| 3. | ALA5238071 | Binding | Inhibition of N-terminal GST-tagged human ALK cytoplasmic domain (1058 to 1620 residues) C1156Y mutant expressed in baculovirus-infected Sf21 cells using LANCE Ultra ULight-PolyGT substrate incubated for 2 hrs by TR-FRET assay | Homo sapiens | 11 | ALA5236584 | cell-based format | Scientific Literature | |
| 4. | ALA5238072 | Binding | Inhibition of N-terminal GST-tagged human ALK cytoplasmic domain (1058 to 1620 residues) L1196M mutant expressed in baculovirus-infected Sf21 cells using LANCE Ultra ULight-PolyGT substrate incubated for 2 hrs by TR-FRET assay | Homo sapiens | 11 | ALA5236584 | cell-based format | Scientific Literature | |
| 5. | ALA5238073 | Functional | Antiproliferative activity against human NCI-H2228 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay | Homo sapiens | 8 | ALA5236584 | cell-based format | Scientific Literature | |
| 6. | ALA5238074 | ADME | Half life in human liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition and measured for 60 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA5236584 | microsome format | Scientific Literature | |
| 7. | ALA5238075 | ADME | Intrinsic clearance in human liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition and measured for 60 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA5236584 | microsome format | Scientific Literature | |
| 8. | ALA5238076 | ADME | Metabolic stability of the compound in human liver microsomes assessed as parent compound remaining at 1 uM preincubated for 5 mins followed by NADPH addition and measured after 60 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA5236584 | microsome format | Scientific Literature | |
| 9. | ALA5238077 | ADME | Half life in mouse liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition and measured for 60 mins by LC-MS/MS analysis | Mus musculus | 3 | ALA5236584 | microsome format | Scientific Literature | |
| 10. | ALA5238078 | ADME | Intrinsic clearance in mouse liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition and measured for 60 mins by LC-MS/MS analysis | Mus musculus | 3 | ALA5236584 | microsome format | Scientific Literature | |
| 11. | ALA5238079 | ADME | Metabolic stability of the compound in mouse liver microsomes assessed as parent compound remaining at 1 uM preincubated for 5 mins followed by NADPH addition and measured after 60 mins by LC-MS/MS analysis | Mus musculus | 3 | ALA5236584 | microsome format | Scientific Literature |
The page will load shortly, Thanks for your patience!