| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5250711 | F | Antitumor activity against human U87 cells xenografted in BALB/c mouse model assessed as decrease in Ki67 positive cells at 20 mg/kg, iv | Homo sapiens | 1 | ALA5247633 | organism-based format | Scientific Literature | |
| 2. | ALA5250712 | T | Toxicity in BALB/c mouse transplanted with human U87 cells assessed as effect in body weight at 20 mg/kg, iv | Mus musculus | 1 | ALA5247633 | organism-based format | Scientific Literature | |
| 3. | ALA5250713 | T | Cytotoxicity against human U251 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay | Homo sapiens | 16 | ALA5247633 | cell-based format | Scientific Literature | |
| 4. | ALA5250714 | F | Antiproliferative activity against human U87 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 16 | ALA5247633 | cell-based format | Scientific Literature | |
| 5. | ALA5250715 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 14 | ALA5247633 | cell-based format | Scientific Literature | |
| 6. | ALA5250716 | F | Antiproliferative activity against human JIMT-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 14 | ALA5247633 | cell-based format | Scientific Literature | |
| 7. | ALA5250717 | F | Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 14 | ALA5247633 | cell-based format | Scientific Literature | |
| 8. | ALA5250718 | F | Antiproliferative activity against human HLF1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 14 | ALA5247633 | cell-based format | Scientific Literature | |
| 9. | ALA5250719 | B | Inhibition of TACC3 in human U87 cells assessed as stabilization of protein by measuring shift in thermal melting curve at 10 uM incubated for 6 hrs by cellular thermal shift assay | Homo sapiens | 1 | ALA5247633 | cell-based format | Scientific Literature | |
| 10. | ALA5250720 | B | Inhibition of TACC3 in human U87 cells assessed as stabilization of protein by measuring shift in thermal melting curve at 10 uM in presence of pronase incubated for 6 hrs by cellular thermal shift assay | Homo sapiens | 1 | ALA5247633 | cell-based format | Scientific Literature | |
| 11. | ALA5250721 | F | Antiproliferative activity against shRNA mediated TACC3 knockdown human U87 cells assessed as reduction in cell viability | Homo sapiens | 1 | ALA5247633 | cell-based format | Scientific Literature | |
| 12. | ALA5250722 | F | Induction of cell cycle arrest in human U87 cells assessed as increase in accumulation at G2/M phase at 2 uM after 24 hrs by propidium iodide staining based flow cytometric analysis | Homo sapiens | 1 | ALA5247633 | cell-based format | Scientific Literature | |
| 13. | ALA5250723 | F | Induction of cell cycle arrest in human U87 cells assessed as increase in accumulation at G2/M phase at 4 uM after 36 hrs by propidium iodide staining based flow cytometric analysis relative to control (Rvb = 15.3 %) | Homo sapiens | 1 | ALA5247633 | cell-based format | Scientific Literature | |
| 14. | ALA5250724 | F | Induction of cell cycle arrest in human U87 cells assessed as decrease in accumulation at G1 phase at 4 uM after 36 hrs by propidium iodide staining based flow cytometric analysis relative to control (Rvb = 51.7 %) | Homo sapiens | 1 | ALA5247633 | cell-based format | Scientific Literature | |
| 15. | ALA5250725 | F | Induction of cell cycle arrest in shRNA induced in human U87 cells assessed as accumulation at G2/M phase at 1 to 4 uM by propidium iodide staining based flow cytometric analysis relative to control (Rvb = 14.95 %) | Homo sapiens | 1 | ALA5247633 | cell-based format | Scientific Literature | |
| 16. | ALA5250726 | A | Stability in mouse plasma assessed as half life | Mus musculus | 1 | ALA5247633 | cell-free format | Scientific Literature | |
| 17. | ALA5250727 | F | Induction of apoptosis in human U87 cells assessed as increase in number of apoptotic cells by Hoechst 33258 staining method | Homo sapiens | 1 | ALA5247633 | cell-based format | Scientific Literature | |
| 18. | ALA5250728 | F | Induction of apoptosis in human U87 cells by AnnexinV/PI staining assay | Homo sapiens | 1 | ALA5247633 | cell-based format | Scientific Literature | |
| 19. | ALA5250729 | F | Induction of apoptosis in human U87 cells assessed as early apoptosis at 4 uM incubated for 36 hrs by AnnexinV/propidium iodide staining based flow cytometry method relative to control (Rvb = 4.49 %) | Homo sapiens | 1 | ALA5247633 | cell-based format | Scientific Literature | |
| 20. | ALA5250730 | F | Induction of apoptosis in human U87 cells assessed as late apoptosis at 4 uM incubated for 36 hrs by AnnexinV/propidium iodide staining based flow cytometry method relative to control (Rvb = 0.52 %) | Homo sapiens | 1 | ALA5247633 | cell-based format | Scientific Literature |
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