# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5238046 | B | Protac activity at BRD4/VHL E3 ligase in human MDA-MB-231 cells assessed as decrease in BRD4 expression at 1 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 4 | ALA5236581 | cell-based format | Scientific Literature | |
2. | ALA5238047 | B | Protac activity at BRD4/VHL E3 ligase in human MDA-MB-231 cells assessed as decrease in BRD4 expression at 1 uM incubated for 8 hrs by Western blot analysis | Homo sapiens | 8 | ALA5236581 | cell-based format | Scientific Literature | |
3. | ALA5238048 | B | Protac activity at BRD4/VHL E3 ligase in human MDA-MB-231 cells assessed as decrease in BRD4 expression at 1 uM incubated for 16 hrs by Western blot analysis | Homo sapiens | 9 | ALA5236581 | cell-based format | Scientific Literature | |
4. | ALA5238049 | B | Protac activity at BRD4/VHL E3 ligase in human MDA-MB-231 cells assessed as decrease in BRD4 expression at 1 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 9 | ALA5236581 | cell-based format | Scientific Literature | |
5. | ALA5238050 | B | Protac activity at BRD4/VHL E3 ligase in human MDA-MB-231 cells assessed as decrease in BRD4 expression at 0.1 nM to 10 uM incubated for 8 hrs by Western blot analysis | Homo sapiens | 6 | ALA5236581 | cell-based format | Scientific Literature | |
6. | ALA5238051 | B | Protac activity at BRD4/VHL E3 ligase in human MDA-MB-231 cells assessed as decrease in BRD4 expression incubated for 8 hrs by Western blot analysis | Homo sapiens | 7 | ALA5236581 | cell-based format | Scientific Literature | |
7. | ALA5238052 | P | Thermodynamic solubility of compound in phosphate buffer at pH 7.4 incubated for 2 hrs with shaking by LC-UV analysis | 6 | ALA5236581 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA5238053 | P | Thermodynamic solubility of compound in HCL at pH 2 incubated for 2 hrs with shaking by LC-UV analysis | 6 | ALA5236581 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA5238054 | A | Metabolic stability in CD-1 mouse liver microsomes assessed as parent compound remaining at 50 uM measured after 1 hr by LC-UV analysis | Mus musculus | 6 | ALA5236581 | microsome format | Scientific Literature |