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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA811867 Binding Compound was tested for inhibition of Tryptophan dioxygenase (TDO) from rat liver 7 ALA1149922 assay format Scientific Literature 2. ALA1817445 ADME Plasma concentration in DBA/2 mouse at 160 mg/kg/day, po administered for 7 days with water Mus musculus 3 ALA1811872 organism-based format Scientific Literature 3. ALA1817446 Binding Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs by HPLC analysis Mus musculus 76 ALA1811872 cell-based format Scientific Literature 4. ALA1817447 Functional Cytotoxicity against mouse P815B cells after 8 hrs by MTT assay Mus musculus 76 ALA1811872 cell-based format Scientific Literature 5. ALA1817448 Physicochemical Chemical stability of the compound in phosphate buffered saline assessed as compound remaining at pH 7.4 after 1.5 hrs 3 ALA1811872 small-molecule physicochemical format Scientific Literature 6. ALA1817449 Binding Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formylkynurenine into kynurenine after 30 mins by Michaelis-Menten steady state analysis Homo sapiens 4 ALA1811872 assay format Scientific Literature 7. ALA1817450 Physicochemical Solubility of the compound in phosphate buffered saline at pH 7.4 3 ALA1811872 small-molecule physicochemical format Scientific Literature 8. ALA2044105 Binding Inhibition of liver TDO 1 ALA2040834 assay format Scientific Literature 9. ALA2044106 Binding Inhibition of human purified TDO assessed as formation of kynurenine from N-formylkynurenine preincubated for 10 mins measured after 5 to 20 mins by discontinuous colorimetric method Homo sapiens 4 ALA2040834 single protein format Scientific Literature 10. ALA3630807 Binding Inhibition of human TDO Homo sapiens 2 ALA3627665 single protein format Scientific Literature 11. ALA3630808 Binding Inhibition of mouse TDO Mus musculus 2 ALA3627665 single protein format Scientific Literature 12. ALA3630809 Binding Inhibition of mouse IDO1 Mus musculus 2 ALA3627665 single protein format Scientific Literature 13. ALA4274902 Binding Inhibition of recombinant human TDO using L-Trp as substrate after 75 mins by UV absorption analysis Homo sapiens 15 ALA4270608 single protein format Scientific Literature 14. ALA4274904 Binding Inhibition of recombinant human TDO at 10 uM using L-Trp as substrate after 75 mins by UV absorption analysis Homo sapiens 15 ALA4270608 single protein format Scientific Literature 15. ALA4274905 Binding Selectivity index, ratio of IC50 for recombinant human TDO to IC50 for human IDO1 Homo sapiens 15 ALA4270608 assay format Scientific Literature 16. ALA4296184 Functional Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020); MIC in CAMBH media, using NBS plates, by OD(600) Staphylococcus aureus 4,588 ALA4296181 organism-based format CO-ADD antimicrobial screening data 17. ALA4296185 Functional Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CAMBH media using NBS plates, by OD(600) Escherichia coli 4,585 ALA4296181 organism-based format CO-ADD antimicrobial screening data 18. ALA4296186 Functional Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); MIC in CAMBH media using NBS plates, by OD(600) Klebsiella pneumoniae 6,160 ALA4296181 organism-based format CO-ADD antimicrobial screening data 19. ALA4296187 Functional Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC in CAMBH media using NBS plates, by OD(600) Pseudomonas aeruginosa 24,161 ALA4296181 organism-based format CO-ADD antimicrobial screening data 20. ALA4296188 Functional Antibacterial activity against Acinetobacter baumannii ATCC 19606 (CO-ADD:GN_034); MIC in CAMBH media using NBS plates, by OD600 Acinetobacter baumannii 22,588 ALA4296181 organism-based format CO-ADD antimicrobial screening data