| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5239751 | B | Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cells incubated for 1 mins under shaking condition followed by 60 mins under dark condition by TR-FRET assay | Homo sapiens | 92 | cell-based format | Scientific Literature | ||
| 2. | ALA5239752 | B | Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cells at 10 uM incubated for 1 mins under shaking condition followed by 60 mins under dark condition by TR-FRET assay relative to control | Homo sapiens | 78 | cell-based format | Scientific Literature | ||
| 3. | ALA5239755 | B | Inverse agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition of receptor basal activity incubated for 24 hrs by luminescence based analysis | Homo sapiens | 40 | cell-based format | Scientific Literature | ||
| 4. | ALA5239756 | B | Inverse agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in receptor basal activity at 10 uM incubated for 24 hrs by luminescence based analysis relative to control | Homo sapiens | 40 | cell-based format | Scientific Literature | ||
| 5. | ALA5239757 | B | Antagonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in rifampicin-induced receptor activation incubated for 24 hrs by luminescence based analysis | Homo sapiens | 60 | cell-based format | Scientific Literature | ||
| 6. | ALA5239758 | B | Antagonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in rifampicin-induced receptor activation at 10 uM incubated for 24 hrs by luminescence based analysis relative to control | Homo sapiens | 60 | cell-based format | Scientific Literature | ||
| 7. | ALA5239759 | B | Agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as transcriptional activation at 30 uM incubated for 24 hrs by luminescence based analysis | Homo sapiens | 64 | cell-based format | Scientific Literature |
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