# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA683045 | B | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 | 144 | ALA1132940 | protein complex format | Scientific Literature | ||
2. | ALA678329 | B | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2 | 146 | ALA1132940 | protein complex format | Scientific Literature | ||
3. | ALA681248 | B | Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2 | 136 | ALA1132940 | protein complex format | Scientific Literature | ||
4. | ALA682251 | B | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2 | 146 | ALA1132940 | protein complex format | Scientific Literature | ||
5. | ALA681480 | B | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2 | 149 | ALA1132940 | protein complex format | Scientific Literature | ||
6. | ALA847928 | B | Selectivity ratio of alpha1 beta-3 gamma2 GABA A / BzR and alpha5 beta-3 gamma2 GABA A / BzR | 67 | ALA1132940 | assay format | Scientific Literature | ||
7. | ALA4135330 | B | Inhibition of TSPO in mouse HT22 cells assessed as reduction in amyloid beta (1 to 42) (unknown origin) induced mitochondrial permeability transition pore formation by measuring increase in green to red fluorescence ratio at 5 uM pretreated for 10 mins followed by amyloid beta (1 to 42) stimulation and measured at 1 hr interval for 3 hrs by JC-1 dye based fluorescence assay relative to control | Mus musculus | 63 | ALA4130502 | cell-based format | Scientific Literature | |
8. | ALA4135331 | B | Inhibition of TSPO in mouse HT22 cells assessed as recovery of ATP production at 5 uM preincubated for 10 mins followed by amyloid beta (1 to 42) stimulation and measured after 7 hrs by luciferase based assay relative to control | Mus musculus | 63 | ALA4130502 | cell-based format | Scientific Literature | |
9. | ALA4135332 | A | Cytotoxicity against mouse HT22 cells as cell viability at 5 uM after 24 hrs by MTT assay relative to control | Mus musculus | 63 | ALA4130502 | cell-based format | Scientific Literature | |
10. | ALA5146040 | B | Displacement of [3H]flunitrazepam from human recombinant alpha1beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand binding assay | Homo sapiens | 21 | ALA5143601 | cell membrane format | Scientific Literature | |
11. | ALA5146041 | B | Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand binding assay | Homo sapiens | 21 | ALA5143601 | cell membrane format | Scientific Literature | |
12. | ALA5146042 | B | Displacement of [3H]flunitrazepam from human recombinant alpha3beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand binding assay | Homo sapiens | 21 | ALA5143601 | cell membrane format | Scientific Literature | |
13. | ALA5146043 | B | Displacement of [3H]flunitrazepam from human recombinant alpha5beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand binding assay | Homo sapiens | 21 | ALA5143601 | cell membrane format | Scientific Literature |