| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3705712 | Binding | Inhibition Assay (Testosterone Hydroxylase): To gain insight into the selectivity of the synthetic compounds, nicotine, nicotine related alkaloids and nicotine metabolites for inhibition of other CYPs, we examined the major CYP present in human liver (i.e., CYP 3A4). That the CYP2A6 inhibitors showed low or no inhibitory activity against CYP3A4 suggests that the inhibitors examined selectively inhibited CYP2A6. | Homo sapiens | 22 | ALA3639082 | assay format | BindingDB Database | |
| 2. | ALA3705713 | Binding | Inhibition Assay: The inhibition of human CYP2A6-mediated 7-hydroxy coumarin formation was evaluated in the presence of 95 selected test compounds in a standard assay (Greenlee et al., J Pharmacol Exp Ther, 1978). Our first studies were with highly purified human CYP2A6 that provided a convenient and relatively high-throughput measure of CYP2A6 inhibition. | Homo sapiens | 89 | ALA3639082 | single protein format | BindingDB Database | |
| 3. | ALA839581 | ADME | Effect on coumarin 7-hydroxylation by human Cytochrome P-450 2A6 | Homo sapiens | 60 | ALA1145288 | single protein format | Scientific Literature | |
| 4. | ALA829411 | ADME | Inhibitory concentration value against human cytochrome P-450 2A6 | Homo sapiens | 25 | ALA1145288 | single protein format | Scientific Literature | |
| 5. | ALA829412 | ADME | Inhibitory concentration value against human cytochrome P-450 2B6 | Homo sapiens | 25 | ALA1145288 | single protein format | Scientific Literature | |
| 6. | ALA829413 | ADME | Inhibitory concentration against human cytochrome P-450 2C9 | Homo sapiens | 25 | ALA1145288 | single protein format | Scientific Literature | |
| 7. | ALA829414 | ADME | Inhibitory concentration value against human cytochrome P-450 2D6 | Homo sapiens | 25 | ALA1145288 | single protein format | Scientific Literature | |
| 8. | ALA829415 | ADME | Inhibitory concentration value against human cytochrome P-450 2E1 | Homo sapiens | 25 | ALA1145288 | single protein format | Scientific Literature | |
| 9. | ALA829416 | ADME | Inhibitory concentration value against human cytochrome P-450 3A4 | Homo sapiens | 25 | ALA1145288 | single protein format | Scientific Literature | |
| 10. | ALA827104 | ADME | Inhibitory concentration value against human cytochrome P-450 2C19 | Homo sapiens | 25 | ALA1145288 | single protein format | Scientific Literature | |
| 11. | ALA832584 | ADME | Ratio of inhibition of human cytochrome P-450 2B6 to 2A6 was determined; Expressed as IC50(CYP2B6)/IC50(CYP2A6) | Homo sapiens | 25 | ALA1145288 | assay format | Scientific Literature | |
| 12. | ALA832585 | ADME | Ratio of inhibition of human cytochrome P-450 2C9 to 2A6 was determined; Expressed as IC50(CYP2C9)/IC50(CYP2A6) | Homo sapiens | 24 | ALA1145288 | assay format | Scientific Literature | |
| 13. | ALA832586 | ADME | Ratio of inhibition of human cytochrome P-450 2D6 to 2A6 was determined; Expressed as IC50(CYP2D6)/IC50(CYP2A6) | Homo sapiens | 25 | ALA1145288 | assay format | Scientific Literature | |
| 14. | ALA832587 | ADME | Ratio of inhibition of human cytochrome P-450 2E1 to 2A6 was determined; Expressed as IC50(CYP2E1)/IC50(CYP2A6) | Homo sapiens | 25 | ALA1145288 | assay format | Scientific Literature | |
| 15. | ALA832588 | ADME | Ratio of inhibition of human cytochrome P-450 3A4 to 2A6 was determined; Expressed as IC50(CYP3A4)/IC50(CYP2A6) | Homo sapiens | 25 | ALA1145288 | assay format | Scientific Literature | |
| 16. | ALA832592 | ADME | Ratio of inhibition of human cytochrome P-450 2C19 to 2A6 was determined; Expressed as IC50(CYP2C19)/IC50(CYP2A6) | Homo sapiens | 25 | ALA1145288 | assay format | Scientific Literature | |
| 17. | ALA4422401 | Binding | Inhibition of human CYP2A6 expressed in insect cell microsomes assessed as reduction in enzyme-mediated coumarin 7-hydroxylation | Homo sapiens | 111 | ALA4421730 | assay format | Patent Bioactivity Data | |
| 18. | ALA4422402 | Binding | Selectivity index, ratio of IC50 for inhibition of human CYP3A4 assessed as reduction in enzyme-mediated testosterone 6-hydroxylation to IC50 for inhibition of human CYP2A6 assessed as reduction in enzyme-mediated coumarin 7-hydroxylation | Homo sapiens | 106 | ALA4421730 | assay format | Patent Bioactivity Data | |
| 19. | ALA4422403 | ADME | Inhibition of CYP3A4 in human liver microsomes assessed as reduction in enzyme-mediated testosterone 6-hydroxylation in presence of NADPH-generating system, G6P and G6P dehydrogenase | Homo sapiens | 106 | ALA4421730 | microsome format | Patent Bioactivity Data | |
| 20. | ALA4422410 | ADME | Inhibition of human CYP2E1 assessed as reduction in specific vivid-blue substrate O-dealkylation by modified PanVera vivid assay protocol based method | Homo sapiens | 43 | ALA4421730 | single protein format | Patent Bioactivity Data |
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