# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA839581 | A | Effect on coumarin 7-hydroxylation by human Cytochrome P-450 2A6 | Homo sapiens | 60 | ALA1145288 | single protein format | Scientific Literature | |
2. | ALA910613 | A | Stability in mouse liver microsome | Mus musculus | 29 | ALA1137358 | organism-based format | Scientific Literature | |
3. | ALA910614 | A | Stability in human liver microsome | Homo sapiens | 29 | ALA1137358 | microsome format | Scientific Literature | |
4. | ALA910617 | A | Inhibition of human CYP2A6 | Homo sapiens | 29 | ALA1137358 | single protein format | Scientific Literature | |
5. | ALA910618 | A | Inhibition of human CYP3A4 | Homo sapiens | 29 | ALA1137358 | single protein format | Scientific Literature | |
6. | ALA910038 | A | Inhibition of human CYP2E1 | Homo sapiens | 29 | ALA1137358 | single protein format | Scientific Literature | |
7. | ALA910039 | A | Inhibition of human CYP2C9 | Homo sapiens | 29 | ALA1137358 | single protein format | Scientific Literature | |
8. | ALA910619 | A | Inhibition of human CYP2C19 | Homo sapiens | 29 | ALA1137358 | single protein format | Scientific Literature | |
9. | ALA910620 | A | Inhibition of human CYP2D6 | Homo sapiens | 29 | ALA1137358 | single protein format | Scientific Literature | |
10. | ALA910621 | A | Inhibition of human CYP2B6 | Homo sapiens | 29 | ALA1137358 | single protein format | Scientific Literature | |
11. | ALA910622 | A | Selectivity for CYP2A6 over CYP3A4 | Homo sapiens | 29 | ALA1137358 | assay format | Scientific Literature | |
12. | ALA910623 | A | Selectivity for CYP2A6 over CYP2E1 | Homo sapiens | 29 | ALA1137358 | assay format | Scientific Literature | |
13. | ALA910624 | A | Selectivity for CYP2A6 over CYP2B6 | 29 | ALA1137358 | assay format | Scientific Literature | ||
14. | ALA910625 | A | Selectivity for CYP2A6 over CYP2C9 | Homo sapiens | 29 | ALA1137358 | assay format | Scientific Literature | |
15. | ALA910626 | A | Selectivity for CYP2A6 over CYP2C19 | Homo sapiens | 29 | ALA1137358 | assay format | Scientific Literature | |
16. | ALA910627 | A | Selectivity for CYP2A6 over CYP2D6 | Homo sapiens | 29 | ALA1137358 | assay format | Scientific Literature | |
17. | ALA3705713 | B | Inhibition Assay: The inhibition of human CYP2A6-mediated 7-hydroxy coumarin formation was evaluated in the presence of 95 selected test compounds in a standard assay (Greenlee et al., J Pharmacol Exp Ther, 1978). Our first studies were with highly purified human CYP2A6 that provided a convenient and relatively high-throughput measure of CYP2A6 inhibition. | Homo sapiens | 89 | ALA3639082 | single protein format | BindingDB Database | |
18. | ALA4422401 | B | Inhibition of human CYP2A6 expressed in insect cell microsomes assessed as reduction in enzyme-mediated coumarin 7-hydroxylation | Homo sapiens | 111 | ALA4421730 | assay format | Patent Bioactivity Data | |
19. | ALA4422402 | B | Selectivity index, ratio of IC50 for inhibition of human CYP3A4 assessed as reduction in enzyme-mediated testosterone 6-hydroxylation to IC50 for inhibition of human CYP2A6 assessed as reduction in enzyme-mediated coumarin 7-hydroxylation | Homo sapiens | 106 | ALA4421730 | assay format | Patent Bioactivity Data | |
20. | ALA4422403 | A | Inhibition of CYP3A4 in human liver microsomes assessed as reduction in enzyme-mediated testosterone 6-hydroxylation in presence of NADPH-generating system, G6P and G6P dehydrogenase | Homo sapiens | 106 | ALA4421730 | microsome format | Patent Bioactivity Data |