# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA664188 | B | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase | Pneumocystis carinii | 66 | ALA1129525 | single protein format | Scientific Literature | |
2. | ALA665590 | B | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase | Toxoplasma gondii | 66 | ALA1129525 | single protein format | Scientific Literature | |
3. | ALA665442 | B | Inhibitory activity against rat liver dihydrofolate reductase | 66 | ALA1129525 | assay format | Scientific Literature | ||
4. | ALA813899 | F | Inhibition of Toxoplasma gondii cell growth | Toxoplasma gondii | 64 | ALA1129525 | organism-based format | Scientific Literature | |
5. | ALA848791 | B | Ratio of IC50 rat liver DHFR vs IC50 of Pneumocystis carinii DHFR | Pneumocystis carinii | 65 | ALA1129525 | assay format | Scientific Literature | |
6. | ALA848792 | B | Ratio of IC50 rat liver DHFR vs IC50 of Toxoplasma gondii DHFR | Pneumocystis carinii | 65 | ALA1129525 | assay format | Scientific Literature | |
7. | ALA5148453 | B | Inhibition of recombinant Trypanosoma brucei PTR1 expressed in Escherichia coli BL21 (DE3) cells using H2B as substrate in presence of cytochrome c and NADPH by envision multilabel reader | Trypanosoma brucei | 34 | ALA5143713 | cell-based format | Scientific Literature | |
8. | ALA5148454 | B | Inhibition of recombinant Leishmania major PTR1 expressed in Escherichia coli BL21 (DE3) cells using H2B as substrate in presence of cytochrome c and NADPH by envision multilabel reader | Leishmania major | 34 | ALA5143713 | cell-based format | Scientific Literature | |
9. | ALA5148455 | B | Inhibition of recombinant Trypanosoma brucei DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NADPH by spectrophotometric analysis | Trypanosoma brucei | 34 | ALA5143713 | cell-based format | Scientific Literature | |
10. | ALA5148456 | B | Inhibition of recombinant Leishmania major DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NADPH by spectrophotometric analysis | Leishmania major | 34 | ALA5143713 | cell-based format | Scientific Literature | |
11. | ALA5148457 | T | Inhibition of recombinant human DHFR expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NADPH by spectrophotometric analysis | Homo sapiens | 34 | ALA5143713 | cell-based format | Scientific Literature | |
12. | ALA5148458 | T | Selectivity index, ratio of IC50 for human DHFR to IC50 for Trypanosoma brucei PTR1 | 34 | ALA5143713 | assay format | Scientific Literature | ||
13. | ALA5148459 | T | Selectivity index, ratio of IC50 for human DHFR to IC50 for Leishmania major PTR1 | 33 | ALA5143713 | assay format | Scientific Literature | ||
14. | ALA5148460 | T | Selectivity index, ratio of IC50 for human DHFR to IC50 for Trypanosoma brucei DHFR | 34 | ALA5143713 | assay format | Scientific Literature | ||
15. | ALA5148461 | T | Selectivity index, ratio of IC50 for human DHFR to IC50 for Leishmania major DHFR | 34 | ALA5143713 | assay format | Scientific Literature | ||
16. | ALA5148466 | T | Inhibition of hERG potassium channel at 10 uM by fluorescence polarization assay relative to control | Homo sapiens | 33 | ALA5143713 | assay format | Scientific Literature | |
17. | ALA5148467 | A | Inhibition of CYP1A2 (unknown origin) expressed in baculovirus-infected insect cells at 10 uM using CYP/Luciferin as substrate incubated for 30 mins in presence of NADPH by luminescence based analysis relative to control | Homo sapiens | 33 | ALA5143713 | cell-based format | Scientific Literature | |
18. | ALA5148468 | A | Inhibition of CYP2C9 (unknown origin) expressed in baculovirus-infected insect cells at 10 uM using CYP/Luciferin as substrate incubated for 30 mins in presence of NADPH by luminescence based analysis relative to control | Homo sapiens | 33 | ALA5143713 | cell-based format | Scientific Literature | |
19. | ALA5148469 | A | Inhibition of CYP2C19 (unknown origin) expressed in baculovirus-infected insect cells at 10 uM using CYP/Luciferin as substrate incubated for 30 mins in presence of NADPH by luminescence based analysis relative to control | Homo sapiens | 33 | ALA5143713 | cell-based format | Scientific Literature | |
20. | ALA5148470 | A | Inhibition of CYP2D6 (unknown origin) expressed in baculovirus-infected insect cells at 10 uM using CYP/Luciferin as substrate incubated for 30 mins in presence of NADPH by luminescence based analysis relative to control | Homo sapiens | 33 | ALA5143713 | cell-based format | Scientific Literature |