# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA835256 | B | Potency against MDM2 (murine double minute-2 gene) binding to p53; Range =100-300 nM | Homo sapiens | 3 | ALA1140309 | protein format | Scientific Literature | |
2. | ALA866340 | B | Displacement of PMDM6-F from human recombinant MDM2 | Homo sapiens | 10 | ALA1148527 | single protein format | Scientific Literature | |
3. | ALA866341 | F | Antiproliferative activity against human LnCAP cell line with wild type p53 | Homo sapiens | 3 | ALA1148527 | cell-based format | Scientific Literature | |
4. | ALA866828 | B | Binding affinity to MDM2 | Homo sapiens | 3 | ALA1138059 | single protein format | Scientific Literature | |
5. | ALA930243 | B | Binding affinity to human HDM2 assessed as inhibition of HDM2-p53 interaction | Homo sapiens | 1 | ALA1142223 | single protein format | Scientific Literature | |
6. | ALA1003083 | B | Binding affinity to human wild type Mdm2 by isothermal titration calorimetry | Homo sapiens | 2 | ALA1156625 | single protein format | Scientific Literature | |
7. | ALA1003086 | B | Binding affinity to human recombinant Mdm2 T101W mutant expressed in Escherichia coli BL21 (DE3) cells by NMR ligand-protein binary titration | Homo sapiens | 2 | ALA1156625 | cell-based format | Scientific Literature | |
8. | ALA1003087 | B | Binding affinity to human recombinant Mdm2 T101W mutant expressed in Escherichia coli BL21 (DE3) cells by antagonist induced dissociation assay | Homo sapiens | 1 | ALA1156625 | cell-based format | Scientific Literature | |
9. | ALA1003088 | B | Binding affinity to human recombinant Mdm2 K98W mutant expressed in Escherichia coli BL21 (DE3) cells by NMR ligand-protein binary titration | Homo sapiens | 1 | ALA1156625 | cell-based format | Scientific Literature | |
10. | ALA1003089 | B | Binding affinity to human recombinant Mdm2 K98W mutant expressed in Escherichia coli BL21 (DE3) cells by antagonist induced dissociation assay | Homo sapiens | 1 | ALA1156625 | cell-based format | Scientific Literature | |
11. | ALA1003090 | B | Binding affinity to human recombinant Mdm2 F55W mutant expressed in Escherichia coli BL21 (DE3) cells by NMR ligand-protein binary titration | Homo sapiens | 2 | ALA1156625 | cell-based format | Scientific Literature | |
12. | ALA992691 | B | Inhibition of interaction between human DM2(1-549) and p53 | Homo sapiens | 1 | ALA1153909 | assay format | Scientific Literature | |
13. | ALA992692 | B | Inhibition of interaction between human DMX(1-555) and p53 at upto 30 uM | Homo sapiens | 1 | ALA1153909 | assay format | Scientific Literature | |
14. | ALA965739 | B | Binding affinity to MDM2 | 2 | ALA1153888 | single protein format | Scientific Literature | ||
15. | ALA1036308 | B | Inhibition of GST-tagged MDM2 (1-150) / full-length His6-tagged p53 interaction expressed in Escherichia coli by alphascreen assay | 2 | ALA1151933 | assay format | Scientific Literature | ||
16. | ALA1036309 | B | Inhibition of GST-tagged MDM2/His6-tagged p53 interaction by surface plasmon resonance study | 1 | ALA1151933 | assay format | Scientific Literature | ||
17. | ALA1052162 | B | Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase reporter assay | Homo sapiens | 7 | ALA1154659 | cell-based format | Scientific Literature | |
18. | ALA1052163 | F | Induction of p21 mRNA in human HCT116 cells by RT-PCR | Homo sapiens | 2 | ALA1154659 | cell-based format | Scientific Literature | |
19. | ALA1052164 | F | Inhibition of human HCT116 cell proliferation after 16 hrs by BrdU assay | Homo sapiens | 2 | ALA1154659 | cell-based format | Scientific Literature | |
20. | ALA1052165 | F | Induction of apoptosis in human SJSA1 cells assessed as caspase 3/7 activity after 48 hrs | Homo sapiens | 2 | ALA1154659 | cell-based format | Scientific Literature |