In vivo activity at a dose of 50 mg/kg, i.p., for 5 doses in mice infected with Trypanosoma brucei brucei STIB 795 strain, measured as survival days (control 13 days)
In vitro inhibitory concentration against P2 aminopurine transporter of Trypanosoma brucei brucei 427 adenosine (0.5 uM) uptake in presence of 1 mM inosine; ND=not determined
Inhibitory concentration in vitro against intracellular amastigotes of Leishmania donovani in rat skeletal myoblasts incubated for 96 hr at 27 degree C
In vitro inhibitory concentration against intracellular amastigotes of Trypanosoma cruzi in rat skeletal myoblasts incubated for 37 degree C for 4 days
In vivo antitrypanosomal activity at a dose of 4*20 mg/kg, i.p., in mice infected with Trypanosoma brucei brucei STIB 795 strain, measured as survival days (control 7 days)
In vivo antitrypanosomal activity at a dose of 4*20 mg/kg, i.p., in mice infected with Trypanosoma brucei rhodesiense STIB 900 strain, measured as survival days (control 7 days)
In vivo activity at a dose of 50 mg/kg, i.p., for 5 doses in mice infected with Trypanosoma brucei brucei STIB 795 strain, measured as survival days (control 13 days)
In vitro inhibitory concentration against blood stream Trypanosoma brucei brucei AT1 knockout mutant with a non functional P2 transporter incubated for 72 h at 37 degree C