In vitro inhibitory concentration against P2 aminopurine transporter of Trypanosoma brucei brucei 427 adenosine (0.5 uM) uptake in presence of 1 mM inosine
Inhibitory concentration in vitro against intracellular amastigotes of Leishmania donovani in rat skeletal myoblasts incubated for 96 hr at 27 degree C
In vitro inhibitory concentration against intracellular amastigotes of Trypanosoma cruzi in rat skeletal myoblasts incubated for 37 degree C for 4 days
In vivo activity at a dose of 25 mg/kg, i.p., for 5 doses in in rodent model with Trypanosoma brucei brucei STIB 795 strain, measured as survival days (control 13 days)
In vivo antitrypanosomal activity at a dose of 4*20 mg/kg, i.p., in mice infected with Trypanosoma brucei brucei STIB 795 strain, measured as survival days (control 7 days)
In vivo antitrypanosomal activity at a dose of 4*20 mg/kg, i.p., in mice infected with Trypanosoma brucei rhodesiense STIB 900 strain, measured as survival days (control 6.5 days)
In vivo percent inhibition of compound at a dose of 25 mg/kg, i.p., for 5 doses in rodent model with Trypanosoma brucei brucei STIB 795 strain; ND is not determined
In vitro inhibitory concentration against blood stream Trypanosoma brucei brucei AT1 knockout mutant with a non functional P2 transporter incubated for 72 h at 37 degree C