#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA863441	B	Inhibition of human gamma-secretase in SHSY5Y neuroblastoma cells	Homo sapiens	29	ALA1147754	cell-based format	Scientific Literature
2.	ALA858782	F	DEA-extractable brain Abeta(40) lowering 4 hrs after oral dosing in APP-YAC mice	Mus musculus	1	ALA1147754	organism-based format	Scientific Literature
3.	ALA3630407	B	Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electrochemiluminescence-based immunoassay	Homo sapiens	12	ALA3627709	cell-based format	Scientific Literature
4.	ALA3630408	B	Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 after 5 to 6 hrs by sandwich immunoassay	Homo sapiens	11	ALA3627709	cell-based format	Scientific Literature
5.	ALA3630409	B	Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 after 5 to 6 hrs by sandwich immunoassay	Homo sapiens	11	ALA3627709	cell-based format	Scientific Literature
6.	ALA3630410	A	AUC (0 to 6 hrs) in Sprague-Dawley rat at 10 mg/kg, po by LC-MS/MS analysis	Rattus norvegicus	7	ALA3627709	organism-based format	Scientific Literature
7.	ALA3630411	A	Ratio of drug level in brain to plasma in Sprague-Dawley rat at 10 mg/kg, po	Rattus norvegicus	4	ALA3627709	organism-based format	Scientific Literature
8.	ALA3630412	B	Selectivity ratio of IC50 for human presenilin-2 to IC50 for human presenilin-1	Homo sapiens	3	ALA3627709	assay format	Scientific Literature
9.	ALA3630413	F	Antialzheimer activity in Sprague-Dawley rat assessed as reduction of total amylod beta level in plasma at 10 mg/kg, po after 3 hrs by immunoassay relative to vehicle-treated control	Rattus norvegicus	3	ALA3627709	organism-based format	Scientific Literature
10.	ALA3630419	A	Inhibition of CYP3A4 (unknown origin) co-incubated with substrate and protein	Homo sapiens	10	ALA3627709	single protein format	Scientific Literature
11.	ALA3630420	A	Inhibition of CYP3A4 (unknown origin) preincubated with protein for 30 mins followed by substrate addition	Homo sapiens	10	ALA3627709	single protein format	Scientific Literature
12.	ALA3630421	A	Inhibition of CYP2D6 (unknown origin) co-incubated with substrate and protein	Homo sapiens	10	ALA3627709	single protein format	Scientific Literature
13.	ALA3630422	A	Inhibition of CYP2D6 (unknown origin) preincubated with protein for 30 mins followed by substrate addition	Homo sapiens	10	ALA3627709	single protein format	Scientific Literature
14.	ALA3630423	A	Inhibition of CYP2C9 (unknown origin) co-incubated with substrate and protein	Homo sapiens	10	ALA3627709	single protein format	Scientific Literature
15.	ALA3630424	A	Inhibition of CYP2C9 (unknown origin) preincubated with protein for 30 mins followed by substrate addition	Homo sapiens	10	ALA3627709	single protein format	Scientific Literature
16.	ALA4303805	F	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	Homo sapiens	5,612	ALA4303101	organism-based format	SARS-CoV-2 Screening Data 2020-21
17.	ALA4428353	B	Inhibition of gamma secretase in HEK293 cells expressing APP assessed as reduction in amyloid beta levels	Homo sapiens	1	ALA4428029	cell-based format	Scientific Literature
18.	ALA4495582	F	SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	7,212	ALA4495564	assay format	SARS-CoV-2 Screening Data 2020-21
19.	ALA4513082	F	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	7,212	ALA4495565	organism-based format	SARS-CoV-2 Screening Data 2020-21
20.	ALA4622183	F	In vivo modulation of gamma secretase in APP-Swedish transgenic mouse assessed as reduction in Abeta42 production by measuring remaining Abeta42 level at 10 mg/kg, po measured after 4 hrs by ELISA or AlphaLISA assay relative to control	Mus musculus	5	ALA4619803	organism-based format	Scientific Literature