# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA864002 | B | Displacement of [3H]-Ro15-1788 from human recombinant GABAA alpha1 in combination with beta-3-gamma-2 expressed in L(tk-) cells | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
2. | ALA864003 | B | Displacement of [3H]-Ro15-1788 from human recombinant GABAA alpha2 in combination with beta3gamma2 expressed in L(tk-) cells | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
3. | ALA864004 | B | Displacement of [3H]Ro-151788 from human recombinant GABAA alpha3 in combination with beta3gamma2 expressed in L(tk-) cells | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
4. | ALA864005 | B | Displacement of [3H]Ro-151788 from human recombinant GABAA alpha5 in combination with beta3gamma2 expressed in L(tk-) cells | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
5. | ALA864006 | F | Efficacy against human recombinant GABAA alpha-1 in combination with beta3gamma2 expressed in L(tk-) cells by whole cell patch clamp method | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
6. | ALA864007 | F | Efficacy against human recombinant GABAA alpha3 in combination with beta-3-gamma-2 expressed in L(tk-) cells by whole cell patch clamp method | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
7. | ALA864008 | F | Efficacy against human recombinant GABAA alpha5 in combination with beta3gamma2 expressed in L(tk-) cells by whole cell patch clamp method | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
8. | ALA2327259 | B | Positive allosteric modulation of GABAA alpha5 (unknown origin) relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
9. | ALA2327260 | B | Positive allosteric modulation of GABAA alpha3 (unknown origin) relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
10. | ALA2327261 | B | Positive allosteric modulation of GABAA alpha2 (unknown origin) relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
11. | ALA2327954 | B | Positive allosteric modulation of GABAA alpha5 (unknown origin) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
12. | ALA2327955 | B | Positive allosteric modulation of GABAA alpha2 (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
13. | ALA2327956 | B | Positive allosteric modulation of GABAA alpha3 (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
14. | ALA3301363 | P | ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 | 4,197 | small-molecule physicochemical format | AstraZeneca Deposited Data | |||
15. | ALA4303805 | F | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging | Homo sapiens | 5,612 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | ||
16. | ALA4403723 | B | Binding affinity to GABA-A alpha1 (unknown origin) assessed as increase in induced current relative to control | Homo sapiens | 23 | single protein format | Scientific Literature | ||
17. | ALA4403724 | B | Binding affinity to GABA-A alpha2 (unknown origin) assessed as increase in induced current relative to control | Homo sapiens | 23 | single protein format | Scientific Literature | ||
18. | ALA4403725 | B | Binding affinity to GABA-A alpha3 (unknown origin) assessed as increase in induced current relative to control | Homo sapiens | 15 | single protein format | Scientific Literature | ||
19. | ALA4403726 | B | Binding affinity to GABA-A alpha5 (unknown origin) assessed as increase in induced current relative to control | Homo sapiens | 15 | single protein format | Scientific Literature | ||
20. | ALA4403727 | B | Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 expressed in Ltk cells | Homo sapiens | 2 | cell-based format | Scientific Literature |