# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA863704 | Binding | Inhibition of human cathepsin K | Homo sapiens | 13 | ALA1138182 | single protein format | Scientific Literature | |
2. | ALA863705 | Binding | Inhibition of human cathepsin L | Homo sapiens | 13 | ALA1138182 | single protein format | Scientific Literature | |
3. | ALA863706 | Binding | Inhibition of human cathepsin V | Homo sapiens | 13 | ALA1138182 | single protein format | Scientific Literature | |
4. | ALA863707 | Binding | Inhibition of human cathepsin S | Homo sapiens | 13 | ALA1138182 | single protein format | Scientific Literature | |
5. | ALA863708 | Binding | Inhibition of human cathepsin B | Homo sapiens | 13 | ALA1138182 | single protein format | Scientific Literature | |
6. | ALA863709 | Binding | Inhibition of rat cathepsin K | Rattus norvegicus | 13 | ALA1138182 | single protein format | Scientific Literature | |
7. | ALA863710 | Functional | Effect on collagen accumulation in osteoclast bone resorption assay | Homo sapiens | 4 | ALA1138182 | cell-based format | Scientific Literature | |
8. | ALA863711 | ADME | Half life in iv dosed Sprague-Dawley rat | Rattus norvegicus | 4 | ALA1138182 | organism-based format | Scientific Literature | |
9. | ALA863712 | ADME | Clearance in iv dosed Sprague-Dawley rat | Rattus norvegicus | 4 | ALA1138182 | organism-based format | Scientific Literature | |
10. | ALA863713 | ADME | Volume of distribution in iv dosed Sprague-Dawley rat | Rattus norvegicus | 4 | ALA1138182 | organism-based format | Scientific Literature | |
11. | ALA863714 | ADME | Oral bioavailability in Sprague-Dawley rat | Rattus norvegicus | 4 | ALA1138182 | organism-based format | Scientific Literature | |
12. | ALA863715 | ADME | Half life in iv dosed cynomolgus monkey | Macaca fascicularis | 2 | ALA1138182 | organism-based format | Scientific Literature | |
13. | ALA863716 | ADME | Clearance in iv dosed cynomolgus monkey | Macaca fascicularis | 2 | ALA1138182 | organism-based format | Scientific Literature | |
14. | ALA863717 | ADME | Volume of distribution in iv dosed cynomolgus monkey | Macaca fascicularis | 2 | ALA1138182 | organism-based format | Scientific Literature | |
15. | ALA863718 | ADME | Oral bioavailability in cynomolgus monkey | Macaca fascicularis | 2 | ALA1138182 | organism-based format | Scientific Literature | |
16. | ALA863719 | ADME | Protein binding in plasma | Rattus norvegicus | 4 | ALA1138182 | cell-free format | Scientific Literature | |
17. | ALA863720 | ADME | Permeability in MDCK cells at 10 uM | Canis lupus familiaris | 4 | ALA1138182 | cell-based format | Scientific Literature | |
18. | ALA863721 | ADME | Permeability in artificial membrane | 4 | ALA1138182 | cell membrane format | Scientific Literature | ||
19. | ALA1120135 | Binding | Selectivity for cathepsin K over cathepsin V | 3 | ALA1155461 | assay format | Scientific Literature | ||
20. | ALA1120143 | ADME | Oral bioavailability in cynomolgus monkey at 2 to 4 mg/kg by LC/MS/MS analysis | Macaca fascicularis | 1 | ALA1155461 | organism-based format | Scientific Literature |