# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA869020 | B | Binding affinity to F9a | Homo sapiens | 4 | ALA1147018 | single protein format | Scientific Literature | |
2. | ALA869021 | F | Anticoagulant potency in human plasma as measured by activated partial thromboplastin time | Homo sapiens | 2 | ALA1147018 | cell-free format | Scientific Literature | |
3. | ALA869022 | F | Anticoagulant potency in human plasma as measured by prothrombin time | Homo sapiens | 2 | ALA1147018 | cell-free format | Scientific Literature | |
4. | ALA869023 | B | Selectivity for F9a over thrombin | 4 | ALA1147018 | assay format | Scientific Literature | ||
5. | ALA869024 | B | Selectivity for F9a over F7a | Homo sapiens | 4 | ALA1147018 | assay format | Scientific Literature | |
6. | ALA869025 | B | Selectivity for F9a over F10a | Homo sapiens | 4 | ALA1147018 | protein format | Scientific Literature | |
7. | ALA858906 | B | Selectivity for F9a over trypsin | Homo sapiens | 2 | ALA1147018 | assay format | Scientific Literature | |
8. | ALA3301366 | A | ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole rat plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. | Rattus norvegicus | 717 | ALA3301361 | cell-free format | AstraZeneca Deposited Data | |
9. | ALA4624394 | B | Inhibition of activated factor IX (unknown origin) using CH3SO2-D-CHG-Gly-Arg-pNA:AcOH as substrate by fluorescence based assay | Homo sapiens | 18 | ALA4622895 | single protein format | Scientific Literature | |
10. | ALA4624395 | A | Inhibition of activated factor X (unknown origin) using CH3O-CO-D-CHG-Gly-Arg-pNA-AcOH as substrate by fluorescence based assay | Homo sapiens | 18 | ALA4622895 | single protein format | Scientific Literature | |
11. | ALA4624396 | B | Selectivity index, ratio of IC50 for activated factor X (unknown origin) to IC50 for activated factor IX (unknown origin) | Homo sapiens | 18 | ALA4622895 | assay format | Scientific Literature | |
12. | ALA4624397 | B | Inhibition of recombinant human activated factor VII using H-D-Lle-Pro-Arg-pNA as substrate by fluorescence based assay | Homo sapiens | 8 | ALA4622895 | single protein format | Scientific Literature | |
13. | ALA4624398 | B | Inhibition of human activated factor XI using pyroGlu-Pro-Arg-pNA as substrate by fluorescence based assay | Homo sapiens | 8 | ALA4622895 | single protein format | Scientific Literature | |
14. | ALA4624403 | A | AUC (0 to 6 hrs) in rat plasma at 10 mg/kg, po | Rattus norvegicus | 5 | ALA4622895 | organism-based format | Scientific Literature |