| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA870213 | F | Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of calcium flux by FLIPR | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
| 2. | ALA869036 | F | Ability to block pore formation in human THP1 cells assessed as inhibition of YO-PRO-1 diiodide dye uptake | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 3. | ALA869037 | F | Antagonist activity at rat P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of calcium flux by FLIPR | Rattus norvegicus | 10 | cell-based format | Scientific Literature | ||
| 4. | ALA869038 | F | Inhibition of ILbeta production in human THP1 cells | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 5. | ALA867516 | F | Reversal of mechanical allodynia in L5/L6 spinal nerve tight ligation model of neuropathic pain in ip dosed rat | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA869039 | F | Reversal of mechanical allodynia in L5/L6 spinal nerve tight ligation model of neuropathic pain in ip dosed rat relative to control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA869040 | A | Oral bioavailability in rat at 10 umol/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA869041 | A | Half life in rat at 10 umol/kg | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA870217 | F | Impairment of motor function in rat by rotarod assay up to 300 umol/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA932852 | F | Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP-induced calcium flux by FLIPR assay | Homo sapiens | 38 | assay format | Scientific Literature | ||
| 11. | ALA932853 | F | Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP-induced calcium flux by FLIPR assay | Rattus norvegicus | 38 | assay format | Scientific Literature | ||
| 12. | ALA1028693 | F | Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptake | Homo sapiens | 94 | cell-based format | Scientific Literature | ||
| 13. | ALA1028698 | B | Activity at rat P2X7 receptor expressed in HEK cells assessed as effect on BzATP-induced ethidium uptake | Rattus norvegicus | 9 | cell-based format | Scientific Literature | ||
| 14. | ALA1030346 | A | Bioavailability in ip dosed rat | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 15. | ALA1030347 | A | Half life in ip dosed rat | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 16. | ALA1780986 | F | Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of benzoylbenzoic ATP-induced calcium production by FLIPR assay | Homo sapiens | 45 | cell-based format | Scientific Literature | ||
| 17. | ALA1780987 | F | Antagonist activity at rat recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of benzoylbenzoic ATP-induced calcium production by FLIPR assay | Rattus norvegicus | 45 | cell-based format | Scientific Literature | ||
| 18. | ALA2411078 | B | Antagonist activity at P2X7 in Sprague-Dawley rat synaptosome assessed as inhibition of BzATP-induced [3H]D-aspartate efflux preincubated at 10 uM for 8 mins by liquid scintillation counting in absence of extracellular Ca2+ | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 19. | ALA2411081 | B | Antagonist activity at P2X7 in Sprague-Dawley rat synaptosome assessed as inhibition of BzATP-induced [3H]D-aspartate efflux preincubated at 10 uM for 8 mins by liquid scintillation counting | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 20. | ALA3214945 | F | PubChem BioAssay. qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (3D7) proliferation. (Class of assay: confirmatory) | 940 | assay format | PubChem BioAssays |
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