# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA866004 | B | Agonist like activity at skeletal junction sarcoplasmic reticulum RyR1/FKBP12 complex assessed as increase in [3H]ryanodine binding | Homo sapiens | 13 | ALA1138036 | protein complex format | Scientific Literature | |
2. | ALA960265 | B | Displacement of [3H]ryanodine from RyR1 calcium channel in sarcoplasmic reticulum assessed as calcium mobilization | 5 | ALA1158892 | single protein format | Scientific Literature | ||
3. | ALA1006192 | B | Binding affinity to RYR1 channels by calcium mobilization assay | 5 | ALA1143439 | single protein format | Scientific Literature | ||
4. | ALA1006193 | B | Activity at RYR2 receptor in rat cerebellar granule neurons assessed as increase in intracellular calcium level at 20 uM | Rattus norvegicus | 3 | ALA1143439 | cell-based format | Scientific Literature | |
5. | ALA1006194 | B | Activity at RYR2 receptor in rat cerebellar granule neurons assessed activation of [45Ca2+] uptake at 20 uM after 10 mins | Rattus norvegicus | 2 | ALA1143439 | assay format | Scientific Literature | |
6. | ALA984030 | F | Antimicrobial activity against Neisseria gonorrhoeae ATCC 49226 after 16 hrs by disk susceptibility test | Neisseria gonorrhoeae | 10 | ALA1158253 | organism-based format | Scientific Literature | |
7. | ALA984031 | F | Antimicrobial activity against Enterococcus faecalis ATCC 29212 after 16 hrs by disk susceptibility test | Enterococcus faecalis | 8 | ALA1158253 | organism-based format | Scientific Literature | |
8. | ALA984032 | F | Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 16 hrs by disk susceptibility test | Staphylococcus aureus | 9 | ALA1158253 | organism-based format | Scientific Literature | |
9. | ALA984033 | F | Antimicrobial activity against Candida albicans ATCC 90028 up to 100 ug/disk after 42 hrs by disk susceptibility test | Candida albicans | 11 | ALA1158253 | organism-based format | Scientific Literature | |
10. | ALA984034 | F | Antimicrobial activity against Cryptococcus neoformans ATCC 90112 up to 100 ug/disk after 42 hrs by disk susceptibility test | Cryptococcus neoformans | 11 | ALA1158253 | organism-based format | Scientific Literature | |
11. | ALA990317 | B | Displacement of [3H]ryanodine from Ry1R/FKBP12 receptor complex in rabbit sarcoplasmic reticulum | Oryctolagus cuniculus | 5 | ALA1158305 | single protein format | Scientific Literature | |
12. | ALA1112436 | F | Antitrypanosomal activity against Trypanosoma brucei brucei 221 after 48 hrs by ATP-bioluminescence assay | Trypanosoma brucei brucei | 9 | ALA1154906 | organism-based format | Scientific Literature | |
13. | ALA1112437 | F | Cytotoxicity against human HCT116 cells after 7 days by methylene blue staining | Homo sapiens | 7 | ALA1154906 | cell-based format | Scientific Literature | |
14. | ALA3225493 | F | Antiproliferative activity against bFGF-treated HUVEC | Homo sapiens | 10 | ALA3217621 | cell-based format | Scientific Literature | |
15. | ALA3225494 | U | Selectivity index, ratio of IC50 for human KB3-1 cells to IC50 for bFGF-treated HUVEC | 10 | ALA3217621 | cell-based format | Scientific Literature | ||
16. | ALA3637317 | B | Inhibition of ACAT in human MDM cells assessed as inhibition of foam cell formation by measuring acetylated LDL-induced [3H]cholesterol ester accumulation at 5 uM after 24 hrs in presence of 0.1 mM [3H]oleate | Homo sapiens | 8 | ALA3632472 | cell-based format | Scientific Literature | |
17. | ALA3637318 | A | Cytotoxicity against human MDM cells at 5 uM after 24 hrs | Homo sapiens | 8 | ALA3632472 | cell-based format | Scientific Literature | |
18. | ALA3637319 | B | Inhibition of human ACAT1 expressed in CHO cells assessed as inhibition of [3H]cholesterol ester accumulation at 5 uM in presence of 0.1 mM [3H]oleate-conjugated BSA | Homo sapiens | 8 | ALA3632472 | cell-based format | Scientific Literature | |
19. | ALA3637434 | B | Inhibition of human ACAT2 expressed in CHO cells assessed as inhibition of [3H]cholesterol ester accumulation at 5 uM in presence of 0.1 mM [3H]oleate-conjugated BSA | Homo sapiens | 8 | ALA3632472 | cell-based format | Scientific Literature |