# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA682932 | B | In vitro inhibition of [3H]FPP incorporation into H-Ras-CVLS by Farnesyl transferase | Homo sapiens | 11 | ALA1132630 | protein complex format | Scientific Literature | |
2. | ALA682705 | B | Inhibitory concentration against farnesyltransferase was determined | Homo sapiens | 17 | ALA1149326 | protein complex format | Scientific Literature | |
3. | ALA739454 | F | In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. | 18 | ALA1132630 | organism-based format | Scientific Literature | ||
4. | ALA739456 | F | In vivo inhibition of geranylgeranylation based on the inhibition of Rap1A processing. | Mus musculus | 18 | ALA1132630 | organism-based format | Scientific Literature | |
5. | ALA770239 | B | In vitro inhibition of [3H]GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I | Homo sapiens | 11 | ALA1132630 | protein complex format | Scientific Literature | |
6. | ALA850690 | F | Relative selectivity for H-Ras farnesylation and Rap1A geranylgeranylation as ratio of IC50s | Mus musculus | 8 | ALA1132630 | assay format | Scientific Literature | |
7. | ALA850692 | B | Relative selectivity farnesyl (Ha-ras-CVLS) and geranylgeranyl (Ha-ras-CVLL) transferases as ratio of IC50s | Homo sapiens | 11 | ALA1132630 | protein complex format | Scientific Literature | |
8. | ALA4185520 | B | Inhibition of FTase isolated from human Burkitt's lymphoma cells assessed as decrease in transfer of [3H]farnesyl from [3H]farnesyl PPi to H-Ras-CVLS | Homo sapiens | 4 | ALA4184146 | assay format | Scientific Literature | |
9. | ALA4185533 | B | Inhibition of GGTase1 isolated from human Burkitt's lymphoma cells assessed as decrease in transfer of [3H]H]geranylgeranyl from [3H]geranylgeranyl PPi to H-Ras-CVLL | Homo sapiens | 1 | ALA4184146 | assay format | Scientific Literature | |
10. | ALA4421915 | B | Inhibition of rat recombinant geranylgeranyltransferase type I expressed in Escherichia coli assessed as reduction in geranylgeranylation of K-Ras4B incubated for 30 mins in presence of [3H]GGPP by scintillation counting assay | Rattus norvegicus | 13 | ALA4421722 | assay format | Patent Bioactivity Data | |
11. | ALA4421916 | B | Inhibition of rat recombinant geranylgeranyltransferase type I expressed in Escherichia coli assessed as reduction in geranylgeranylation of RhoA incubated for 30 mins in presence of [3H]GGPP by scintillation counting assay relative to control | Rattus norvegicus | 87 | ALA4421722 | assay format | Patent Bioactivity Data | |
12. | ALA4421946 | B | Inhibition of FTase in HEK293 cells assessed as reduction in H-ras farnesylation at 5 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis | Homo sapiens | 1 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
13. | ALA5150202 | F | Antitumor activity against mouse NIH3T3 cells transfected with KRAS4B xenografted nude mouse assessed as inhibition of tumor growth at 35 mg/kg, ip administered in the presence of FTI-276 relative to control | Mus musculus | 1 | ALA5149962 | organism-based format | Scientific Literature | |
14. | ALA5150204 | F | Antitumor activity against mouse NIH3T3 cells transfected with H-Ras CVLS xenografted nude mouse assessed as inhibition of tumor growth at 70 mg/kg, ip administered once daily relative to control | Mus musculus | 1 | ALA5149962 | organism-based format | Scientific Literature | |
15. | ALA5150206 | F | Antitumor activity against human Calu-1 cells transfected with KRAS mutant xenografted nude mouse assessed as inhibition of tumor growth at 70 mg/kg, ip administrated once daily measure for 40 to 80 days relative to control | Homo sapiens | 1 | ALA5149962 | organism-based format | Scientific Literature |