Antimicrobial activity against paromomycin-resistant Streptomyces coelicolor SP2 harboring rpsL K88E mutant gene and inserted glycine at position 92 of the gene after 48 hrs
Increase in human F9 nonsense R338X mutant antigen level per 100 ul of plasma in C57B/6J mouse model at 7 mg/kg, sc administered daily for 2 days after 2 hrs by ELISA
Increase in human F9 nonsense R338X mutant antigen level per 100 ul of plasma in C57B/6J mouse model at 14 mg/kg, sc administered daily for 2 days after 2 hrs by ELISA
Increase in human F9 nonsense R338X mutant antigen coagulant activity in C57B/6J mouse plasma at 14 mg/kg, sc administered daily for 2 days after 2 hrs
Increase in human F9 nonsense R338X mutant antigen level per 100 ul of plasma in C57B/6J mouse model at 28 mg/kg, sc administered daily for 2 days after 2 hrs by ELISA
Increase in human F9 nonsense R338X mutant antigen coagulant activity in C57B/6J mouse plasma at 28 mg/kg, sc administered daily for 2 days after 2 hrs
Increase in human F9 nonsense R338X mutant antigen level per 100 ul of plasma in C57B/6J mouse model at 28 mg/kg, sc administered daily for 2 days after 9 hrs by ELISA
Increase in human F9 nonsense R338X mutant antigen coagulant activity in C57B/6J mouse plasma at 28 mg/kg, sc administered daily for 2 days after 9 hrs
Increase in human F9 nonsense R338X mutant antigen level per 100 ul of plasma in C57B/6J mouse model at 42 mg/kg, sc administered daily for 2 days after 9 hrs by ELISA
Increase in human F9 nonsense R338X mutant antigen coagulant activity in C57B/6J mouse plasma at 42 mg/kg, sc administered daily for 2 days after 9 hrs
Increase in human F9 nonsense R338X mutant antigen coagulant activity in C57B/6J mouse plasma at 28 mg/kg, sc administered daily for 7 days after 9 hrs by ELISA