# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA920408 | B | Stabilization of Pu27 oligomer by inducing G-quadruplex formation assessed as inhibition of hybridization with Pu27rev by PCR stop assay | 10 | assay format | Scientific Literature | |||
2. | ALA904232 | B | Inhibition of Pu27 oligomer hybridization with Pu27rev at 18 uM by PCR stop assay | 5 | assay format | Scientific Literature | |||
3. | ALA904234 | B | Inhibition of Pu27-13, 14 oligomer hybridization with Pu27rev at 36 uM by PCR stop assay | 10 | assay format | Scientific Literature | |||
4. | ALA914883 | B | Inhibition of telomerase by TRAP assay | Homo sapiens | 11 | assay format | Scientific Literature | ||
5. | ALA914882 | P | Dissociation constant, pKa of the compound | 11 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA914881 | B | Induction of G-quadruplex in G-rich human telomere 21 DNA assessed as circular dichroism spectral change at 50 uM | Homo sapiens | 10 | assay format | Scientific Literature | ||
7. | ALA996761 | B | Binding affinity to oligonucleotide HTG21 by florescence titration assay in presence of K+ solution | 5 | nucleic acid format | Scientific Literature | |||
8. | ALA996762 | B | Binding affinity to F21T human telomeric DNA assessed as change in melting temperature at 1 uM by FRET assay | Homo sapiens | 5 | nucleic acid format | Scientific Literature | ||
9. | ALA996763 | B | Binding affinity to F10T hairpin duplex DNA assessed as change in melting temperature at 1 uM by FRET assay | 5 | nucleic acid format | Scientific Literature | |||
10. | ALA1024712 | B | Binding affinity to synthetic HTG21 telomere assessed as change in G-qudraplex DNA melting temperature at 2 uM by FRET method | 25 | assay format | Scientific Literature | |||
11. | ALA1024713 | B | Inhibition of amplification of synthetic HTG21 telomere assessed as G-quadruplex stabilization by PCR | 25 | assay format | Scientific Literature | |||
12. | ALA1024719 | B | Inhibition of telomerase in human MCF7 cells by cell-free telomerase repeat amplification protocol assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
13. | ALA2155828 | B | Binding affinity to c-myc Pu27 DNA G-quadruplex in human CA46 cells assessed as down regulation of c-myc protein expression at 0.05 to 0.1 uM after 4 days by Western blot method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA2155829 | B | Binding affinity to c-myc Pu27 DNA G-quadruplex in human Ramos cells assessed as down regulation of TERT protein expression at 0.05 to 0.1 uM after 4 days by Western blot method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA2155830 | B | Binding affinity to c-myc Pu27 DNA G-quadruplex in human CA46 cells assessed as down regulation of TERT transcription at 0.1 uM after 4 days by qRT-PCR | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
16. | ALA2155831 | B | Binding affinity to c-myc Pu27 DNA G-quadruplex in human Ramos cells assessed as down regulation of c-myc protein expression at 0.05 to 0.1 uM after 4 days by Western blot method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA2155832 | B | Binding affinity to c-myc Pu27 DNA G-quadruplex in human Ramos cells assessed as down regulation of c-myc transcription at 0.1 uM after 4 days by qRT-PCR | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA2155833 | B | Binding affinity to c-myc Pu27 DNA G-quadruplex in human Ramos cells assessed as down regulation of TERT transcription at 0.1 uM after 4 days by qRT-PCR | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA2155834 | B | Binding affinity to c-myc Pu27 DNA G-quadruplex in human CA46 cells assessed as down regulation of c-myc transcription at 0.1 uM after 4 days by qRT-PCR | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
20. | ALA2155835 | B | Inhibition of NM23-H2 interaction with c-myc DNA G-quadruplex in human HeLa cells assessed as inhibition of c-myc expression at 0.1 uM measured by quantitative RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |