# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA905370 | Binding | Inhibition of phospholipase B activity of PLB1 in Cryptococcus neoformans var. grubii H99 assessed as loss of 1,2-di[1-14C]palmitoyl phosphatidylcholine at 250 uM | Cryptococcus neoformans var. grubii | 5 | ALA1143035 | single protein format | Scientific Literature | |
2. | ALA905382 | Functional | Antifungal activity against Cryptococcus neoformans ATCC 90112 | Cryptococcus neoformans | 17 | ALA1143035 | organism-based format | Scientific Literature | |
3. | ALA905383 | Functional | Antifungal activity against Candida albicans ATCC 10231 | Candida albicans | 17 | ALA1143035 | organism-based format | Scientific Literature | |
4. | ALA905392 | ADME | Cytotoxicity against human erythrocytes assessed as hemolytic activity at 500 uM | Homo sapiens | 15 | ALA1143035 | cell-based format | Scientific Literature | |
5. | ALA3227786 | Binding | Inhibition of CHKA in human HCT116 cells assessed as [3H]phosphocholine formation using [3H]choline chloride as substrate at 2.4 +/-1 uM incubated for 1 hr prior to substrate addition measured after 1 hr by scintillation counting analysis | Homo sapiens | 2 | ALA3217582 | cell-based format | Scientific Literature | |
6. | ALA3227787 | Binding | Inhibition of CHKA in human HCT116 cells assessed as [3H]phosphocholine formation using [3H]choline chloride as substrate at 6.5 +/-4 uM incubated for 1 hr prior to substrate addition measured after 1 hr by scintillation counting analysis | Homo sapiens | 2 | ALA3217582 | cell-based format | Scientific Literature | |
7. | ALA3227788 | Functional | Growth inhibition of human A549 cells overexpressing CHKA2 after 72 hrs by sulforhodamine assay | Homo sapiens | 11 | ALA3217582 | cell-based format | Scientific Literature | |
8. | ALA3227789 | Binding | Inhibition of CHKA in human HCT116 cells assessed as [3H]phosphocholine formation using [3H]choline chloride as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by scintillation counting analysis | Homo sapiens | 2 | ALA3217582 | cell-based format | Scientific Literature | |
9. | ALA3227790 | Functional | Growth inhibition of human HCT116 cells overexpressing CHKA2 after 72 hrs by sulforhodamine assay | Homo sapiens | 11 | ALA3217582 | cell-based format | Scientific Literature | |
10. | ALA3227792 | Binding | Competitive inhibition of recombinant delta49N CHKA2 (unknown origin) using 72 uM choline as substrate by Lineweaver-burk plot analysis in presence of 10 uM to 5 mM ATP | Homo sapiens | 1 | ALA3217582 | assay format | Scientific Literature | |
11. | ALA3227793 | Binding | Competitive inhibition of recombinant delta49N CHKA2 (unknown origin) using 40 uM to 20 mM choline as substrate by Lineweaver-burk plot analysis in presence of 450 uM ATP | Homo sapiens | 1 | ALA3217582 | assay format | Scientific Literature | |
12. | ALA3227794 | Binding | Inhibition of recombinant delta49N CHKA2 (unknown origin) assessed as ADP formation using choline as substrate by enzyme coupled assay | Homo sapiens | 11 | ALA3217582 | assay format | Scientific Literature |