# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA631418 | Physicochemical | Calculated partition coefficient (clogP) | 27 | ALA1135513 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA678910 | Binding | Direct activation of human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 | 27 | ALA1135513 | protein complex format | Scientific Literature | ||
3. | ALA678911 | Binding | Potentiation of GABA responses at human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 | 27 | ALA1135513 | protein complex format | Scientific Literature | ||
4. | ALA858286 | Functional | Loss of righting reflex (LORR) in tadpoles was determined for anesthetic activity | frog | 26 | ALA1135513 | organism-based format | Scientific Literature | |
5. | ALA914538 | Functional | Activity against caspase-mediated apoptosis in mouse L1210 cells | Mus musculus | 52 | ALA1139474 | cell-based format | Scientific Literature | |
6. | ALA914539 | ADME | Cytotoxicity against mouse L1210 cells | Mus musculus | 96 | ALA1139474 | cell-based format | Scientific Literature | |
7. | ALA956074 | Binding | Inhibition of human erythrocyte CA1 esterase activity using 4-nitrophenyl acetate substrate | Homo sapiens | 11 | ALA1153923 | single protein format | Scientific Literature | |
8. | ALA956075 | Binding | Inhibition of human erythrocyte CA2 esterase activity using 4-nitrophenyl acetate substrate | Homo sapiens | 11 | ALA1153923 | single protein format | Scientific Literature | |
9. | ALA722977 | Functional | Hypnotic activity was measured as dose which causes loss of righting reflex for a minimum period of 30s in 50% of mice; Range is 80-100 | Mus musculus | 2 | ALA1121624 | organism-based format | Scientific Literature | |
10. | ALA726035 | Toxicity | Acute toxicity measured as median lethal dose in mice | Mus musculus | 28 | ALA1121624 | organism-based format | Scientific Literature | |
11. | ALA4219940 | Binding | Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced response at 5.9 uM by fluorescence based HTS assay | Homo sapiens | 9 | ALA4219040 | cell-based format | Scientific Literature | |
12. | ALA4219941 | Binding | Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux at 10 uM by HT assay | Homo sapiens | 9 | ALA4219040 | cell-based format | Scientific Literature | |
13. | ALA4219942 | Binding | Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux by HT assay | Homo sapiens | 9 | ALA4219040 | cell-based format | Scientific Literature | |
14. | ALA4219943 | Binding | Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC5 to EC10 glycine-induced response at 10 uM by manual patch clamp assay | Homo sapiens | 9 | ALA4219040 | cell-based format | Scientific Literature | |
15. | ALA4219948 | Binding | Allosteric modulation of GlyRalpha3 in VGAT::ChR2 BAC transgenic mouse lumbar spinal cord slices assessed as increase in decay time constants of light-evoked Gly-IPSC at 100 uM by Whole cell patch clamp method | Mus musculus | 1 | ALA4219040 | assay format | Scientific Literature | |
16. | ALA4219949 | Binding | Allosteric modulation of zymosan-A treated GlyRalpha3 in VGAT::ChR2 BAC transgenic mouse lumbar spinal cord slices assessed as increase in decay time constants of light-evoked Gly-IPSC at 100 uM by Whole cell patch clamp method | Mus musculus | 1 | ALA4219040 | assay format | Scientific Literature | |
17. | ALA4219950 | Functional | Analgesic activity in zymosan-A induced inflammation mouse model assessed as reduction in mechanical hyperalgesia | Mus musculus | 1 | ALA4219040 | organism-based format | Scientific Literature | |
18. | ALA4219951 | Functional | Analgesic activity in zymosan-A induced inflammation GlyR3 knock out mouse model assessed as reduction in mechanical hyperalgesia | Mus musculus | 1 | ALA4219040 | organism-based format | Scientific Literature |