# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA895648 | B | Displacement of [125I]IABN from human dopamine D2 receptor expressed in HEK293 cells | Homo sapiens | 23 | ALA1148745 | cell-based format | Scientific Literature | |
2. | ALA894567 | B | Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cells | Homo sapiens | 23 | ALA1148745 | cell-based format | Scientific Literature | |
3. | ALA895647 | B | Displacement of [125I]IABN from human dopamine D4 receptor expressed in HEK293 cells | Homo sapiens | 23 | ALA1148745 | cell-based format | Scientific Literature | |
4. | ALA895649 | B | Selectivity for human dopamine D3 receptor over human dopamine D2 receptor | Homo sapiens | 23 | ALA1148745 | protein format | Scientific Literature | |
5. | ALA895655 | B | Binding affinity to human 5HT1A receptor | Homo sapiens | 20 | ALA1148745 | single protein format | Scientific Literature | |
6. | ALA895656 | B | Binding affinity to human 5HT2A receptor | Homo sapiens | 20 | ALA1148745 | single protein format | Scientific Literature | |
7. | ALA895657 | B | Binding affinity to human 5HT2C receptor | Homo sapiens | 20 | ALA1148745 | single protein format | Scientific Literature | |
8. | ALA895658 | B | Selectivity for human dopamine D3 receptor over human 5HT1A receptor | Homo sapiens | 20 | ALA1148745 | assay format | Scientific Literature | |
9. | ALA895659 | B | Selectivity for human dopamine D3 receptor over human 5HT2A receptor | Homo sapiens | 20 | ALA1148745 | assay format | Scientific Literature | |
10. | ALA895660 | B | Selectivity for human dopamine D3 receptor over human 5HT2C receptor | Homo sapiens | 20 | ALA1148745 | assay format | Scientific Literature | |
11. | ALA3705176 | B | Binding Assay: Methods for performing in vitro dopamine receptor binding studies are described in Huang et al. J. Med. Chem. 44:1815-1826 (2001) and Luedtke et al. Synapse 38:438-439 (2000). These papers describe radioactively labeled dopamine receptor selective ligands binding with picomolar affinity and nonselectivity to D2 and D3 dopamine receptors expressed in Sf9 and HEK 293 cells. 125I-IABN binds with 7- to 10-fold lower affinity to human D4.4 dopamine receptors expressed in HEK 293 cells. Dissociation constants (Kd) calculated from kinetic experiments were found to be in agreement with equilibrium Kd values obtained from saturation binding studies. Saturation plots of the binding of 125I-IABN with rat caudate membrane preparations were monophasic and exhibited low nonspecific binding. | Homo sapiens | 29 | ALA3638880 | cell-based format | BindingDB Database |