# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA895698 | Binding | Displacement of [125I]ghrelin from ovine recombinant GHSR1a expressed in HEK293F cells after 6 hrs by scintillation proximity assay | Ovis aries | 38 | ALA1148824 | cell-based format | Scientific Literature | |
2. | ALA895699 | Functional | Agonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelin | Homo sapiens | 27 | ALA1148824 | cell-based format | Scientific Literature | |
3. | ALA895700 | Functional | Antagonist activity at human recombinant GHSR1a expressed in HEK293F cells by [35S]GTP-gamma-S binding assay | Homo sapiens | 27 | ALA1148824 | cell-based format | Scientific Literature | |
4. | ALA895702 | ADME | Cmax in Wistar rat at 3 mg/kg, po | Rattus norvegicus | 27 | ALA1148824 | organism-based format | Scientific Literature | |
5. | ALA896830 | Binding | Displacement of [125I]DIO from 5HT2c receptor | Homo sapiens | 9 | ALA1148824 | single protein format | Scientific Literature | |
6. | ALA896831 | Physicochemical | Aqueous solubility at pH 7.2 | 9 | ALA1148824 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA896832 | ADME | Inhibition of CYP2D6 | 9 | ALA1148824 | single protein format | Scientific Literature | ||
8. | ALA3227232 | Binding | Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis | Homo sapiens | 41 | ALA3217433 | cell-based format | Scientific Literature | |
9. | ALA3301362 | Physicochemical | ASTRAZENECA: Most basic pKa value (pKa B1) determined by absorption and potentiometric titration using standard methodology from Sirius Analytical. Experimental range Bases: >= 2. | 261 | ALA3301361 | small-molecule physicochemical format | AstraZeneca Deposited Data | ||
10. | ALA3301363 | Physicochemical | ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 | 4,197 | ALA3301361 | small-molecule physicochemical format | AstraZeneca Deposited Data | ||
11. | ALA3301370 | ADME | ASTRAZENECA: Intrinsic clearance measured in human liver microsomes following incubation at 37C. Experimental range <3 to >150 microL/min/mg. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736. | Homo sapiens | 1,102 | ALA3301361 | microsome format | AstraZeneca Deposited Data | |
12. | ALA3301371 | ADME | ASTRAZENECA: Intrinsic clearance measured in rat hepatocytes following incubation at 37C. Experimental range <3 to >150 microL/min/1E6 cells. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736 | Rattus norvegicus | 837 | ALA3301361 | cell-based format | AstraZeneca Deposited Data |