# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA895698 | Binding | Displacement of [125I]ghrelin from ovine recombinant GHSR1a expressed in HEK293F cells after 6 hrs by scintillation proximity assay | Ovis aries | 38 | ALA1148824 | cell-based format | Scientific Literature | |
2. | ALA895699 | Functional | Agonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelin | Homo sapiens | 27 | ALA1148824 | cell-based format | Scientific Literature | |
3. | ALA895700 | Functional | Antagonist activity at human recombinant GHSR1a expressed in HEK293F cells by [35S]GTP-gamma-S binding assay | Homo sapiens | 27 | ALA1148824 | cell-based format | Scientific Literature | |
4. | ALA895702 | ADME | Cmax in Wistar rat at 3 mg/kg, po | Rattus norvegicus | 27 | ALA1148824 | organism-based format | Scientific Literature | |
5. | ALA895703 | ADME | Clearance in Wistar rat at 1 mg/kg iv | Rattus norvegicus | 1 | ALA1148824 | organism-based format | Scientific Literature | |
6. | ALA896830 | Binding | Displacement of [125I]DIO from 5HT2c receptor | Homo sapiens | 9 | ALA1148824 | single protein format | Scientific Literature | |
7. | ALA896831 | Physicochemical | Aqueous solubility at pH 7.2 | 9 | ALA1148824 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA896832 | ADME | Inhibition of CYP2D6 | 9 | ALA1148824 | single protein format | Scientific Literature | ||
9. | ALA896837 | ADME | AUC in Wistar rat plasma at 3 mg/kg, po | Rattus norvegicus | 2 | ALA1148824 | organism-based format | Scientific Literature | |
10. | ALA896838 | ADME | Cmax in Wistar rat plasma at 3 mg/kg, po | Rattus norvegicus | 2 | ALA1148824 | organism-based format | Scientific Literature | |
11. | ALA896839 | ADME | Bioavailability in Wistar rat plasma at 3 mg/kg, po | Rattus norvegicus | 3 | ALA1148824 | organism-based format | Scientific Literature | |
12. | ALA896840 | ADME | AUC (0-t) in Wistar rat plasma at 1 mg/kg, iv | 1 | ALA1148824 | organism-based format | Scientific Literature | ||
13. | ALA896841 | ADME | Cmax in Wistar rat plasma at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA1148824 | organism-based format | Scientific Literature | |
14. | ALA896842 | ADME | Half life in Wistar rat plasma at 1 mg/kg, iv | 1 | ALA1148824 | organism-based format | Scientific Literature | ||
15. | ALA896843 | ADME | Volume of distribution in Wistar rat plasma at 1 mg/kg, iv | 1 | ALA1148824 | organism-based format | Scientific Literature | ||
16. | ALA896845 | Functional | Decrease in food intake in DIO C57BL/6 mouse at 30 mg/kg, po after 24 hrs relative to control | Mus musculus | 2 | ALA1148824 | organism-based format | Scientific Literature | |
17. | ALA896847 | Functional | Decrease in body weight in DIO C57BL/6 mouse at 30 mg/kg, po after 9 days | Mus musculus | 2 | ALA1148824 | organism-based format | Scientific Literature | |
18. | ALA896848 | ADME | Cmax in po dosed DIO C57BL/6 mouse after 5 hrs | Mus musculus | 5 | ALA1148824 | organism-based format | Scientific Literature | |
19. | ALA896849 | ADME | Drug level in po dosed DIO C57BL/6 mouse brain after 5 hrs relative to plasma concentration | Mus musculus | 5 | ALA1148824 | organism-based format | Scientific Literature | |
20. | ALA896850 | Functional | Increase in food intake in DIO C57BL/6 mouse at 30 mg/kg, after 5 hrs relative to control | Mus musculus | 5 | ALA1148824 | organism-based format | Scientific Literature |